Water soluble zanthylium derivative substrates
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United States of America Patent
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Jan 31, 1989
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N/A
app pub date -
Jun 18, 1987
filing date -
May 28, 1985
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Abstract
Water soluble xanthylium derivative substrates of rhodamine 110 and rhodol permit spectrophotometric and fluorescent measurements of trypsin-like enzymes without the addition of organic solvent additives and/or special water solubilizing agents. These novel substrates exhibit increased sensitivity for determining low levels of activity of trypsin-like enzymes such as proteolytic enzymes, cofactors, activators, antiactivators, and inhibitors. These substrates can be substituted for fibrinogen to monitor the pathways of blood coagulation.
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