Immunological emulsion adjuvants for polysaccharide vaccines
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United States of America Patent
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Feb 7, 1989
Grant Date -
N/A
app pub date -
Apr 15, 1986
filing date -
Apr 15, 1986
priority date (Note) -
Expired
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Abstract
An immunological adjuvant for polysaccharide vaccines is provided whereby polysaccharide antigens are rendered more immunogenic and thus stimulate more antibody production including an IgG response and immunological memory. The adjuvant is comprised of (1) either (A) an emulsion system containing a metabolizable oil, a low molecular weight polyol and lecithin, or (B) an oil-in-water emulsion system containing a light hydrocarbon non-biodegradable oil or a biodegradable oil, and a detergent; and (2) a refined detoxified endotoxin. The adjuvant can optionally also contain trehalose dimycolate.
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