Erodible matrix for sustained release bioactive composition
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United States of America Patent
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Feb 21, 1989
Issued Date -
N/A
app pub date -
Oct 14, 1986
filing date -
Jul 23, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A sustained release composition for releasing a biologically active compound into an aqueous liquid environment comprises said biologically active compound dispersed in a bioerodible matrix, the matrix comprising a mixture of (a.) 5% to 95% by weight of a solid water-dispersible polyether diol having a molecular weight from about 1000 to about 20,000K selected from the group consisting of polyethylene glycols and polyethylene oxide-polypropylene oxide block copolymers, and (b.) 95 to 5% by weight of an erosion rate modifier which is an amphiphilic compound insoluble in the aqueous liquid. Dosage forms comprising the erodible matrix are prepared by molding, particularly by injection molding.
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