Iburprofen sustained release matrix and process
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United States of America Patent
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-
Feb 21, 1989
Grant Date -
N/A
app pub date -
Apr 22, 1987
filing date -
Apr 22, 1987
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
An ibuprofen-sustained release tablet or tablet layer is formed by making a wet granulation using providone (PVP) in alcohol as the granulating fluid which is mixed with ibuprofen, ethylcellulose, a wicking agent e.g. microcrystalline cellulose, an erosion promoter e.g. pregelatinized starch, then drying and milling the granulation and blending with dry powdered erosion promotor, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the ibuprofen.
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