Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
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United States of America Patent
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Feb 28, 1989
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N/A
app pub date -
Aug 10, 1984
filing date -
Jul 9, 1984
priority date (Note) -
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Abstract
A conjugate, which is the reductive amination product of an immunogenic capsular polymer fragment, having a reducing end and derived from the capsular polymer of a bacterial pathogen, and the non-toxic polypeptide binding subunit of the heat-labile enterotoxin of Escherichia coli (LT-BNT). Also disclosed, are methods for the preparation of the conjugates and for the preparation of vaccines containing the conjugates which elicits an effective level of antibodies in humans. By administering an immunogenic amount of the conjugates, active immunization against systematic infection in young mammals caused by bacterial pathogens can be induced.
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