Device for the controlled release of drugs with Donnan-like modulation by charged insoluble resins
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United States of America Patent
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-
Mar 21, 1989
Grant Date -
N/A
app pub date -
Aug 31, 1987
filing date -
Aug 31, 1987
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The instant invention is directed to a drug delivery device for the controlled release of beneficial agents and drugs into an environment of use comprising: (A) a core composition comprising (a) a water insoluble, non-diffusible charged resin entity, and (b) a diffusible, water soluble ionizable therapeutically active ingredient carrying the same charge as said resin entity; and (B) a substantially imperforate water-insoluble wall surrounding said core composition, prepared from a semipermeable material substantially impermeable to the core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a hole(s) for release of the therapeutic agent through the water insoluble wall.
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