US Patent No: 4,814,436

Number of patents in Portfolio can not be more than 2000

Derivative of .alpha., .alpha.-trehalose and a process for preparing the same

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ATTORNEY / AGENT: (SPONSORED)
 

Importance

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Abstract

Derivatives of .alpha.,.alpha.-trehalose-6,6'-fatty acid diester having phosphoric ester groups in the molecule which are useful as a carcinostatic agent. One of the derivatives may be prepared by reacting diphenylphosphoryl chloridate with a derivative of 2,3,2',3'-tetra-O-benzyl-.alpha.,.alpha.-trehalose-6,6'-fatty acid diester. Another derivative may be obtained by substituting benzyl groups at 2,3,2',3' positions of trehalose with hydrogen atoms.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
SS PHARMACEUTICAL CO., LTD.TOKYO89

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Katori, Tatsuhiko Tone, JP 21 92
Kohya, Hidehiko Narita, JP 7 38
Matsuda, Hideaki Natori, JP 95 657
Shibata, Akihiro Takatsuki, JP 35 152

Cited Art

Patent Info (Count) # Cites Year
 
SS PHARMACEUTICAL CO., LTD. (2)
4,684,719 .alpha.,.alpha.-trehalose fatty acid diester derivative 29 1985
4,612,304 Antitumor formulation containing lipopolysaccharide with trehalose derivatives 7 1985
 
WINTERSHALL AG (1)
4,720,456 Trehalose lipid tetraesters 8 1986

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
QUADRANT DRUG DELIVERY LIMITED (9)
6,632,648 Methods of terminal sterilization of fibrinogen 1 1996
6,468,782 Methods of preserving prokaryotic cells and compositions obtained thereby 17 1997
6,586,006 Solid delivery systems for controlled release of molecules incorporated therein and methods of making same 30 2001
6,811,792 Solid dose delivery vehicle and methods of making same 114 2002
6,893,657 Solid dose delivery vehicle and methods of making same 10 2003
7,056,495 Solid dose delivery vehicle and methods of making same 82 2003
7,785,631 Solid dose delivery vehicle and methods of making same 0 2005
7,780,991 Solid dose delivery vehicle and methods of making same 0 2005
7,744,925 Solid dose delivery vehicle and methods of making same 0 2005
 
NOVARTIS AG (7)
7,871,598 Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use 0 2000
8,168,223 Engineered particles and methods of use 0 2001
7,306,787 Engineered particles and methods of use 9 2002
7,521,069 Methods and compositions for pulmonary delivery of insulin 6 2003
8,404,217 Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use 0 2005
8,246,934 Respiratory dispersion for metered dose inhalers comprising perforated microstructures 0 2010
8,349,294 Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use 0 2010
 
NOVARTIS PHARMA AG (2)
7,300,919 Pulmonary delivery of active fragments of parathyroid hormone 5 2002
7,628,978 Stabilized preparations for use in metered dose inhalers 3 2003
 
QDOSE LIMITED (2)
6,290,991 Solid dose delivery vehicle and methods of making same 51 1994
6,565,871 Solid dose delivery vehicle and methods of making same 35 2001
 
KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (1)
5,576,303 Energy-supplementing saccharide source and its uses 7 1994
 
QUADRANT HOLDINGS CAMBRIDGE LIMITED (1)
6,331,310 Solid dose delivery vehicle and methods of making same 44 2000
 
SAWAI PHARMACEUTICAL CO., LTD. (1)
5,049,664 Trehalose derivatives 4 1989