Derivative of .alpha., .alpha.-trehalose and a process for preparing the same

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 4814436
SERIAL NO

06938883

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Abstract

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Derivatives of .alpha.,.alpha.-trehalose-6,6'-fatty acid diester having phosphoric ester groups in the molecule which are useful as a carcinostatic agent. One of the derivatives may be prepared by reacting diphenylphosphoryl chloridate with a derivative of 2,3,2',3'-tetra-O-benzyl-.alpha.,.alpha.-trehalose-6,6'-fatty acid diester. Another derivative may be obtained by substituting benzyl groups at 2,3,2',3' positions of trehalose with hydrogen atoms.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
SS PHARMACEUTICAL CO., LTD.TOKYO5

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Katori, Tatsuhiko Tone, JP 21 112
Kohya, Hidehiko Sendai, JP 7 44
Matsuda, Hideaki Abiko, JP 105 875
Shibata, Akihiro Narashino, JP 63 364

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Wintershall Aktiengesellschaft (1)
* 4720456 Trehalose lipid tetraesters 10 1986
 
SS Pharmaceutical Co., Ltd. (2)
* 4684719 .alpha.,.alpha.-trehalose fatty acid diester derivative 35 1985
* 4612304 Antitumor formulation containing lipopolysaccharide with trehalose derivatives 8 1985
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
SAWAI PHARMACEUTICAL CO., LTD. (1)
* 5049664 Trehalose derivatives 5 1989
 
Other [Check patent profile for assignment information] (3)
* 2003/0113,900 Methods of preserving prokaryotic cells and compositions obtained thereby 15 2002
* 2004/0219,206 Solid dose delivery vehicle and methods of making same 40 2004
* 2009/0203,576 METHODS AND COMPOSITONS FOR PULMONARY DELIVERY OF INSULIN 0 2009
 
QUADRANT HOLDINGS CAMBRIDGE LIMITED (1)
6331310 Solid dose delivery vehicle and methods of making same 80 2000
 
QDOSE LIMITED (2)
6290991 Solid dose delivery vehicle and methods of making same 110 1994
6565871 Solid dose delivery vehicle and methods of making same 88 2001
 
QUADRANT DRUG DELIVERY LIMITED (14)
6632648 Methods of terminal sterilization of fibrinogen 10 1996
6468782 Methods of preserving prokaryotic cells and compositions obtained thereby 34 1997
6586006 Solid delivery systems for controlled release of molecules incorporated therein and methods of making same 81 2001
6811792 Solid dose delivery vehicle and methods of making same 182 2002
6893657 Solid dose delivery vehicle and methods of making same 23 2003
* 2003/0147,961 Solid dose delivery vehicle and methods of making same 0 2003
7056495 Solid dose delivery vehicle and methods of making same 125 2003
* 2004/0052,825 Solid dose delivery vehicle and methods of making same 4 2003
7785631 Solid dose delivery vehicle and methods of making same 8 2005
7780991 Solid dose delivery vehicle and methods of making same 3 2005
7744925 Solid dose delivery vehicle and methods of making same 9 2005
* 2005/0276,759 Solid dose delivery vehicle and methods of making same 19 2005
* 2005/0276,845 Solid dose delivery vehicle and methods of making same 7 2005
* 2007/0249,033 Methods of terminal sterilization of biological products 0 2007
 
NOVARTIS AG (17)
7871598 Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use 1 2000
8168223 Engineered particles and methods of use 5 2001
7306787 Engineered particles and methods of use 55 2002
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7521069 Methods and compositions for pulmonary delivery of insulin 37 2003
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8404217 Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use 0 2005
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8715623 Pulmonary delivery of aminoglycoside 1 2007
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8349294 Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use 0 2010
8877162 Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery 0 2012
9439862 Phospholipid-based powders for drug delivery 0 2014
9421166 Pulmonary delivery of aminoglycoside 0 2014
 
KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (1)
* 5576303 Energy-supplementing saccharide source and its uses 8 1994
 
NOVARTIS PHARMA AG (12)
* 2003/0035,778 Methods and compositions for the dry powder formulation of interferon 15 2002
7300919 Pulmonary delivery of active fragments of parathyroid hormone 15 2002
* 2003/0171,282 Pulmonary delivery of active fragments of parathyroid hormone 5 2002
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* 2007/0065,369 NOVEL METHODS AND COMPOSITION FOR DELIVERING MACROMOLECULES TO OR VIA THE RESPIRATORY TRACT 1 2006
* 2007/0122,418 COMPOSITIONS AND METHODS FOR THE PULMONARY DELIVERY OF AEROSOLIZED MEDICAMENTS 1 2007
* 2008/0075,782 Pulmonary delivery of active fragments parathyroid hormone 0 2007
* Cited By Examiner