US Patent No: 4,818,418

Number of patents in Portfolio can not be more than 2000

Blood partitioning method

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Abstract

The present invention is directed to a method for separating mononuclear cells from other cells in a blood sample which is more rapid than the currently used density gradient material and which provides a better separation than methods utilizing thixotropic, gel-like material. In the method, a water soluble density gradient material is placed in a centrifuged tube. A water insoluble, thixotropic, gel-like substance is also placed in the container. A blood sample is placed in the container and the container is centrifuged for a time during which various components interchange positions and the gel-like substance forms a barrier between the mononuclear cells and the other cells of the blood sample.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BECTON, DICKINSON AND COMPANYFRANKLIN LAKES, NJ2398

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Saunders, Alex M 8 Trillium La., San Carlos, CA 94070 10 170

Cited Art

Patent Info (Count) # Cites Year
 
BECTON, DICKINSON AND COMPANY (4)
4,190,535 Means for separating lymphocytes and monocytes from anticoagulated blood 61 1978
4,350,593 Assembly, compositions and method for separating blood 49 1979
4,417,981 Blood phase separator device 77 1981
4,640,785 Separation of lymphocytes and monocytes from blood samples 19 1984
 
ORTHO DIAGNOSTIC SYSTEMS INC. (2)
4,435,293 Particle washing system and method of use 25 1981
4,436,631 Multiple particle washing system and method of use 32 1982
 
SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA (2)
4,457,782 Composition for partitioning blood components 20 1981
4,534,798 Composition for partitioning blood components 13 1983
 
BECTON DICKINSON MONOCOLONAL CENTER (1)
4,751,001 Blood partitioning apparatus 34 1984
 
TECHNICON INSTRUMENTS CORPORATION (1)
4,487,700 Method and apparatus for separating lymphocytes from anticoagulated blood 25 1983
 
TERUMO KABUSHIKI KAISHA (1)
4,310,430 .alpha.-Olefin-dialkylmaleate-based liquid separating agent 23 1980
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (1)
4,255,256 Medium for the separation of human blood leucocytes 28 1979

Patent Citation Ranking

Forward Cites

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7,960,121 Methods and compositions for diagnosing and monitoring transplant rejection 1 2010
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LABORATORY CORPORATION OF AMERICA HOLDINGS (6)
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7,166,231 Red blood cell separation method 8 2003
7,297,272 Separation apparatus and method 3 2004
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7,789,245 Blood separation chamber 2 2009
 
BECTON, DICKINSON AND COMPANY (4)
4,867,887 Method and apparatus for separating mononuclear cells from blood 30 1988
4,954,264 Apparatus for separating mononuclear cells from blood and method of manufacturing and using the same 14 1989
7,309,468 Protease inhibitor sample collection system 11 2003
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GENETIX CORP (2)
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