Method of preparing particles suitable for tabletting into diagnostic reagents
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United States of America Patent
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Apr 11, 1989
Grant Date -
N/A
app pub date -
Mar 24, 1986
filing date -
Mar 24, 1986
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A completely water-soluble, solid, labile biochemical-containing diagnostic reagent is prepared without the need of a lyophilization step, by spraying, preferably by a fluidized bed process, an aqueous solution of labile biochemical, e.g., an enzyme, onto small particles, e.g., lower than 20 mesh, of an inert, completely water-soluble solid bulking agent, e.g., mannitol; drying the resultant labile biochemical-coated bulking agent to the desired dryness; and then forming resultant dried labile biochemical-coated bulking agent into a tablet suitable for a diagnostic test reagent, said tablet having a predetermined rate of dissolution.
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