Importance

Loading Importance Indicators...

Abstract

The invention refers to compounds having anti-inflammatory activity, characterized by the formula ##STR1## in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents in the carbon atom at position 20, in which formula the 1,2 position is saturated or is a double bond, X.sub.1 is hydrogen, fluorine, chlorine or bromine, X.sub.2 is hydrogen, fluorine, chlorine or bromine, R.sub.1 is hydrogen or methyl, R.sub.2 is a straight or branched hydrocarbon chain having 1-10 carbon atoms and R.sub.3 is hydrogen or a straight or branched chain alkyl group having 1-12 carbon atoms, a lower alkyl group substituted by 1-5 halogen atoms or an unsubstituted or substituted phenyl or benzyl group, provided that when R.sub.1 is methyl R.sub.2 is a hydrocarbon chain having 2-10 carbon atoms. The invention also refers to a process and intermediates for the preparation of these compounds, a pharmaceutical preparation containing one of the compounds and a method for the treatment of inflammatory conditions.

Loading the Abstract Image...

First Claim