Effervescent couples, histamine H.sub.2 -antagonist effervescent compositions containing them and their preparation
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United States of America Patent
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Apr 25, 1989
Grant Date -
N/A
app pub date -
Jan 20, 1987
filing date -
Jan 22, 1986
priority date (Note) -
Expired
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Abstract
The invention relates to an effervescent couple which comprises a mixture of mono-and di-alkali metal citrate as well as to a process for preparing same. The process comprises partially neutralizing citric acid by reacting an alkali metal carbonate or bicarbonate with citric acid and water and controlling the amount of carbon dioxide released during the reaction by stopping the reaction when a certain amount of citric acid has been neutralized. In a preferred embodiment the reaction is stopped when from about 24% to about 54% of the potential amount of carbon dioxide has been released.
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