Antineoplastic enamine derivatives of daunorubicin and adriamycin

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United States of America Patent

PATENT NO 4824944
SERIAL NO

07002050

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Abstract

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The present invention relates to new enamine derivatives of daunorubicin and adriamycin of the formula l: ##STR1## and formula 2: ##STR2## wherein R denotes a hydrogen atom or hydroxyl group. The inventive compounds are useful antineoplastic antibiotics utilized in the treatment of cancer, primarily leukemia. The present derivatives demonstrate a reduction in toxicity, in particular cardiotoxicity, over their parent compounds, while retaining chemotherapeutic properties.

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Patent Owner(s)

Patent OwnerAddress
POLITECHNIKA GDANSKAUL NARUTOWICZA 11/12 GDANSK PL-80-952

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Borowski, Edward Gdansk, PL 14 37
Falkowski, Leonard S Gdansk, PL 4 20
Stefanska, Barbara J Gdansk, PL 4 20

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