Hypocholesterolemically active RNA fractions
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United States of America Patent
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Apr 25, 1989
Grant Date -
N/A
app pub date -
Dec 23, 1985
filing date -
Dec 24, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Hypocholesterolemically active RNA fractions having the following characteristics: (a) Molecular weight by gel filtration: 11,000.+-.9,000 (b) Base composition ratio of nucleic acid: uracil:guanine:cytosine:adenine=1:1:2:1 (c) Infrared absorption spectrum: shown in FIG. 2 (d) Physiological characteristics: having a hypocholesterolemic activity in mammals. These hypocholesterolemically active RNA fractions can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypocholesterolemically active RNA fractions from the cultured cells of the microorganism. These hypocholesterolemically active RNA fractions can be used as an active ingredient of a hypocholesterolemic or antiatherosclerotic pharmaceutical composition together with a pharmaceutically acceptable carrier therefor to form a hypocholesterolemic or antiatherosclerotic pharmaceutical compositions, which is suitable for oral administration to mammals.
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