Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
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United States of America Patent
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May 9, 1989
Grant Date -
N/A
app pub date -
Apr 24, 1987
filing date -
Apr 24, 1987
priority date (Note) -
Expired
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Abstract
Substituted imidazolyl-alkyl-piperazine and diazepine derivatives of Formula A: ##STR1## wherein: R.sup.1 is aryl, lower alkyl, cycloalkyl or hydrogen; R.sup.2 is aryl, lower alkyl or hydrogen; R.sup.3 is lower alkyl, hydroxy, or hydrogen; R.sup.4 is aryl or hydrogen; R.sup.5 is aryl or hydrogen; m is two or three; n is zero, one or two, provided that when R.sup.3 is hydroxy, n is one or two; and q is zero, one, two, or three; and the pharmaceutically acceptable salts thereof, are calcium channel antagonists useful for treating mammals having a variety of disease states, such as stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism and also for treatment of spinal injuries.
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