Hypocholesterolemically and/or hypotriglyceridemically active RNA fractions
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United States of America Patent
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May 23, 1989
Grant Date -
N/A
app pub date -
Jun 23, 1986
filing date -
Jul 3, 1985
priority date (Note) -
Expired
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Abstract
Hypocholesterolemically and/or hypotriglyceridemically active RNA fractions having the following characteristics: (a) Molecular weight by gel filtration: 2,000.+-.1,000 (b) Base composition ratio of nucleic acid: uracil: guanine: cytosine: adenine=13.0: 16.0: 16.0: 10.0 (c) Infrared absorption sepctrum: shown in FIG. 2 (d) Physiological characteristics: having a hypocholesterolemic and/or hypotriglyceridemic activity in mammals. These hypocholesterolemically and/or hypotriglyceridemically active RNA fractions can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypocholesterolemically and/or hypotriglyceridemically active RNA fractions from the cultured cells of the microorganism. These hypocholesterolemically and/or hypotriglyceridemically active RNA fractions can be used as an active ingredient of a hypocholesterolemic or hypotriglyceridemic pharmaceutical composition together with a pharmaceutically acceptable carrier therefor to form a hypocholesterolemic or hypotriglyceridemic pharmaceutical composition, which is suitable for oral administration to mammals.
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