Controlled release pharmaceutical composition
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United States of America Patent
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May 30, 1989
Issued Date -
N/A
app pub date -
Nov 12, 1987
filing date -
Jul 26, 1985
priority date (Note) -
Expired
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Abstract
A solid, controlled release pharmaceutical composition is provided with enhanced levels of control over drug release. The composition comprises an acid addition salt or a quarternary ammonium salt of an organic base drug complexed with an anionic surfactant and distributed in a matrix of a hydrophilic polymer. The complex formation between the drug which is preferably an acid addition salt of an organic an organic amine, and the surfactant, which is preferably a sulphosuccinate, distributed in the hydrophilic polymer matrix, which is preferably a water soluble hydroxyalkylcelulose ether results in a composition with excellent controlled released characteristics.
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