US Patent No: 4,834,978

Number of patents in Portfolio can not be more than 2000

Method of transdermal drug delivery

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ATTORNEY / AGENT: (SPONSORED)
 

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Abstract

A transdermal drug delivery system useful for the controlled, for example, zero order, release of one or more drugs to a selected skin area of a user, which system comprises a reservoir containing a transdermal delivery composition. The reservoir contains a composition which comprises a base material, which is a solid but which melts or liquefies upon contact with the skin of a user and selected to occlude the skin of the user to force hydration of the stratum corneum with water from the lower layers of the epidermis of the user and a plurality of solid microparticles, generally uniformly dispersed and suspended in the base material, the microparticles containing an effective, therapeutic amount of the drug for transdermal delivery, such as the contraceptive steroid. In use, the base material forms a thermodynamically stable thin film layer in intimate contact with the skin while the drug is released from the microparticles into the base material and transdermally into the user through the thin liquid film of the base material.

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First Claim

Related Publications

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BIOTEK, INC.WOBURN, MA18

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nuwayser, Elie S Woburn, MA 14 547

Cited Art

Patent Info (Count) # Cites Year
 
BIOTEK, INC. (1)
4,624,665 Method of transdermal drug delivery 97 1984

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (5)
6,002,961 Transdermal protein delivery using low-frequency sonophoresis 104 1995
5,814,599 Transdermal delivery of encapsulated drugs 230 1995
6,018,678 Transdermal protein delivery or measurement using low-frequency sonophoresis 86 1995
5,947,921 Chemical and physical enhancers and ultrasound for transdermal drug delivery 112 1995
6,041,253 Effect of electric field and ultrasound for transdermal drug delivery 241 1996
 
ECHO THERAPEUTICS, INC. (4)
7,066,884 System, method, and device for non-invasive body fluid sampling and analysis 97 2001
8,287,483 Method and apparatus for enhancement of transdermal transport 0 2004
8,224,414 System and method for analyte sampling and analysis with hydrogel 0 2005
8,386,027 Skin permeation device for analyte sensing or transdermal drug delivery 0 2008
 
DURECT CORPORATION (3)
8,246,977 Transdermal delivery systems 0 2005
8,252,319 Transdermal delivery system for sufentanil 0 2007
8,252,320 Transdermal delivery system for sufentanil 0 2007
 
LTS LOHMANN THERAPIE-SYSTEME GMBH (3)
5,230,898 Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof 38 1990
5,702,721 Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof 7 1994
6,117,437 Pharmaceutical form for delivery of active substances to wounds 5 1997
 
AMERICARE TECHNOLOGIES, INC. (2)
5,405,614 Electronic transdermal drug delivery system 95 1993
5,932,240 Multidose transdermal drug delivery system 14 1997
 
JENCAP RESEARCH LTD. (2)
5,276,022 Hormone preparation and method 26 1991
5,256,421 Hormone preparation and method 31 1992
 
SONTRA MEDICAL, INC. (2)
6,234,990 Ultrasound enhancement of transdermal transport 71 1997
6,491,657 Ultrasound enhancement of transdermal transport 33 2001
 
APTALIS PHARMATECH, INC. (1)
5,008,114 Pharmaceutical compositions with controlled release, and a method for their preparation 25 1988
 
COATING SCIENCES, INC. (1)
5,498,417 Transdermal delivery of appetite suppressant drug 16 1994
 
DRUG DELIVERY SYSTEMS INC. (1)
5,991,655 Iontophoretic drug delivery device and method of manufacturing the same 24 1998
 
ECHO THERAPEUTICS (1)
7,432,069 Biocompatible chemically crosslinked hydrogels for glucose sensing 2 2005
 
EXSYMOL S.A.M. (1)
5,264,207 Products for cutaneous applications with cosmetic and/or therapeutic effects 27 1990
 
INTERNATIONAL MEDICAL ASSOCIATES, INC. (1)
5,756,117 Multidose transdermal drug delivery system 18 1992
 
INTERVET INTERNATIONAL B.V. (1)
RE39592 Extended release growth promoting two component composition 0 2004
 
MCNEIL AB (1)
5,230,896 Transdermal nicotine delivery system 28 1989
 
MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. (1)
8,287,923 Compositions and methods for treating immune disorders 0 2006
 
MEDIPRO SCIENCES LIMITED (1)
5,462,743 Substance transfer system for topical application 25 1993
 
NOVARTIS AG (1)
5,364,628 Pharmaceutical compositions 8 1993
 
NOVARTIS;CORPORATE INTELLECTUAL PROPERTY (1)
5,128,124 Transdermal therapeutic system for active ingredient combinations 12 1991
 
PERICOR SCIENCE, INC. (1)
6,958,148 Linkage of agents to body tissue using microparticles and transglutaminase 7 2000
 
POPULATION COUNCIL, INC., THE (1)
5,651,973 Therapeutically effective topical application of ST1435 2 1992
 
TEIKOKU SEIYAKU KABUSHIKI KAISHA (1)
5,827,529 External preparation for application to the skin containing lidocaine 35 1994
 
TRANSDERMAL TECHNOLOGIES PTY LIMIITED (1)
5,308,621 Ascorbic acid composition and transdermal administration method 22 1991
 
VENTURE CORPORATION (1)
5,730,721 Medical applicator and method 12 1996