US Patent No: 4,834,978

Number of patents in Portfolio can not be more than 2000

Method of transdermal drug delivery

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Abstract

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A transdermal drug delivery system useful for the controlled, for example, zero order, release of one or more drugs to a selected skin area of a user, which system comprises a reservoir containing a transdermal delivery composition. The reservoir contains a composition which comprises a base material, which is a solid but which melts or liquefies upon contact with the skin of a user and selected to occlude the skin of the user to force hydration of the stratum corneum with water from the lower layers of the epidermis of the user and a plurality of solid microparticles, generally uniformly dispersed and suspended in the base material, the microparticles containing an effective, therapeutic amount of the drug for transdermal delivery, such as the contraceptive steroid. In use, the base material forms a thermodynamically stable thin film layer in intimate contact with the skin while the drug is released from the microparticles into the base material and transdermally into the user through the thin liquid film of the base material.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BIOTEK, INC.WOBURN, MA0

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nuwayser, Elie S Wellesley, MA 14 697

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Biotek, Inc. (1)
* 4,624,665 Method of transdermal drug delivery 157 1984
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
VENTURE CORPORATION (1)
* 5,730,721 Medical applicator and method 20 1996
 
NOVARTIS CORPORATION (1)
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NOVARTIS AG (1)
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PERICOR SCIENCE, INC. (2)
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MASSACHUSETTS INSTITUTE OF TECHNOLOGY (6)
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* 5,947,921 Chemical and physical enhancers and ultrasound for transdermal drug delivery 203 1995
* 6,041,253 Effect of electric field and ultrasound for transdermal drug delivery 355 1996
* 2004/0210,184 Effect of electric field and ultrasound for transdermal drug delivery 53 2004
 
SONTRA MEDICAL CORPORATION (1)
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JENCAP RESEARCH LTD. (2)
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SONTRA MEDICAL, INC. (3)
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Medipro Sciences Limited (1)
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MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. (3)
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ECHO THERAPEUTICS (2)
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MCNEIL AB (1)
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THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (1)
9,114,133 Method of improving diastolic dysfunction 0 2012
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
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Exsymol S.A.M. (1)
* 5,264,207 Products for cutaneous applications with cosmetic and/or therapeutic effects 27 1990
 
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Echo Therapeutics, Inc. (10)
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8,386,027 Skin permeation device for analyte sensing or transdermal drug delivery 9 2008
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8,870,810 Method and apparatus for enhancement of transdermal transport 0 2012
 
LOCL PHARMA, INC. (4)
8,653,066 Pharmaceutical compositions 0 2007
* 2010/0143,469 PHARMACEUTICAL COMPOSITIONS 4 2007
8,728,522 Pharmaceutical compositions for treating or preventing pain 2 2010
9,226,901 Pharmaceutical compositions 0 2013
 
Teikoku Seiyaku Kabushiki Kaisha (1)
* 5,827,529 External preparation for application to the skin containing lidocaine 86 1994
 
COATING SCIENCES, INC. (1)
* 5,498,417 Transdermal delivery of appetite suppressant drug 18 1994
 
INTERNATIONAL MEDICAL ASSOCIATES, INC. (1)
* 5,756,117 Multidose transdermal drug delivery system 27 1992
 
INTERVET INTERNATIONAL B.V. (1)
RE39592 Extended release growth promoting two component composition 0 2004
 
DURECT CORPORATION (3)
8,246,977 Transdermal delivery systems 0 2005
8,252,319 Transdermal delivery system for sufentanil 0 2007
8,252,320 Transdermal delivery system for sufentanil 0 2007
 
LTS LOHMANN THERAPIE-SYSTEME AG (1)
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AMERICARE TECHNOLOGIES, INC. (2)
* 5,405,614 Electronic transdermal drug delivery system 137 1993
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CHARLESTON LABORATORIES, INC. (1)
9,198,867 Pharmaceutical compositions 0 2012
 
POPULATION COUNCIL INC. (1)
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LTS Lohmann Therapie-Systeme GmbH & Co. KG (3)
* 5,230,898 Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof 47 1990
* 5,702,721 Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof 24 1994
* 6,117,437 Pharmaceutical form for delivery of active substances to wounds 10 1997
* Cited By Examiner