Agonists and antagonists to nicotine as smoking deterents
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United States of America Patent
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May 30, 1989
Grant Date -
N/A
app pub date -
Feb 12, 1987
filing date -
Feb 12, 1987
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Agonists and antagonists to nicotine are used as smoking deterrents. The nicotinic antagonists have the following structural requirements: (1) Aromatic, cycloalkyl, and heterocyclic carbamic acid esters of di- and trialkylaminoalkyl alcohols. (2) Aromatic, cycloalkyl, and heterocyclic thiocarbamic acid esters of di-and trialkylaminoalkyl alcohols. (3) Aromatic, cycloalkyl, and heterocyclic carboxylic acid esters of di-and trialkylaminoalkyl alcohols. (4) Aromatic, cycloalkyl, and heterocyclic carboxylic acid esters of heterocyclic amino alcohols. (5) Lobelia alkaloids: lobeline, lobelanine, and lobelanidine. The nicotinic agonists (nicotine-like) have the following structural requirements: (1) methylcarbamic acid esters of di- and trialkylaminoalkyl alcohols. (2) methylthiocarbamic acid esters of di- and trialkylaminoalkyl alcohols.
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