Specific inhibitors of tissue kallikrein
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United States of America Patent
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May 30, 1989
Grant Date -
N/A
app pub date -
Apr 3, 1987
filing date -
Apr 3, 1987
priority date (Note) -
Expired
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Abstract
A unique class of tissue kallikrein inhibitors is provided which are specific for tissue kallikreins and do not substantially cross-react with plasma kallikreins or other serine proteases in-vivo. These inhibitors are substrate analogues of low molecular weight kininogens but are highly inhibitory, stable and resistant to enzymatic hydrolysis, and release non-toxic degradation products.
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