Liposomes with enhanced retention on mucosal tissue
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United States of America Patent
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Jun 13, 1989
Grant Date -
N/A
app pub date -
Jul 28, 1986
filing date -
Jul 28, 1986
priority date (Note) -
Expired
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Abstract
A liposome composition designed for enhanced binding to mucosal tissue, The liposomes contain about 10-40 mole percent of an amine-derivatized lipid component in which a charged amine group is spaced from a lipid polar head region by a carbon-containing spacer arm at least 3 atoms in length. The liposomes preferably have a close packed lipid structure produced by inclusion of between 20-50 mole percent of cholesterol or an amine-derivatized cholesterol, and/or phospholipids with predominantly saturated acyl chain moieties. For ophthalmic use, the liposomes may be suspended in an aqueous medium containing a high-viscosity polymer, to enhance further the retention of liposomes on a corneal surface.
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