High temperature method for the production of ribavirin

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United States of America Patent

PATENT NO 4840898
SERIAL NO

07097762

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Abstract

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A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine and the temperature during at least a part of the reaction is at or above 65.degree. C. The method is capable of high production rates and high concentrations of the final product.

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Patent Owner(s)

Patent OwnerAddress
EASTMAN KOKAK COMPANY A NEW JERSEY CORPROCHESTER NY 14650

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lievense, Jefferson C Rochester, NY 6 103
Sawyer, Joanna D Littleton, CO 1 1
Terpolilli, Anthony J Rochester, NY 1 1

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