Method for the production of ribavirin using high robose donor concentrations
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United States of America Patent
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Jun 20, 1989
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N/A
app pub date -
Sep 17, 1987
filing date -
Sep 17, 1987
priority date (Note) -
Expired
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Abstract
A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine; the concentration of the donor is above about 100 mM; and the enzyme preparation is added before the reaction mixture gells. The method is capable of high production rates and high concentration of the final product.
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