Concentrated stabilized microbubble-type ultrasonic imaging agent
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United States of America Patent
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Jul 4, 1989
Grant Date -
N/A
app pub date -
Dec 29, 1987
filing date -
Dec 29, 1987
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A microbubble-type ultrasonic imaging agent is provided comprising a parenterally-administerable aqueous medium containing a dispersion of microspheres predominantly of diameters less than 10 microns, wherein the microspheres consist of gas microbubbles encapsulated with water-insolubilized biocompatible material. The imaging agent is characterized by having a concentration of greater than 100.times.10.sup.6 microspheres per milliliter, and a stability such that this concentration is maintained for over 4 weeks at a temperature of 20.degree. to 25.degree. C.
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