Spheroids

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 4844910
SERIAL NO

07122747

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ATTORNEY / AGENT: (SPONSORED)

Importance

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Abstract

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A controlled release pharmaceutical composition comprising a plurality of film coated spheroids, the film coated spheroids comprising a 3-alkylxanthine, a non-water soluble spheronising agent and between 4% and 9% (by weight) water, wherein the in-vitro dissolution rate of the 3-alkylxanthine from the film coated spheroids, when measured by the USP Paddle Method at 100 rpm in 900 ml aqueous buffer (pH 6.5 at 37.degree. C.) is between 7.5% and 25.0% (by wt) release after 1 hour, between 22.5% and 45.0% (by wt) release after 2 hours, between 40.0% and 60.0% (by wt) release after 3 hours, between 50.0% and 75.0% (by wt) release after 4 hours, between 70.0% and 92.5% (by wt) release after 6 hours, and between 80.0% and 100.0% (by wt) release after 8 hours. Preferably the water content is between 4% and 8%, especially between 4% and 7% (by wt) of the film coated spheroid formulation. The preferred 3-alkylxanthine is theophylline (anhydrous or hydrate), whilst the preferred spheronising agent is microcrystalline cellulose.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
EURO-CELTIQUE S.A.LUXEMBOURG88
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURGSTAMFORD, CT0

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Leslie, Stewart T Cambridge, GB3 24 2264
Malkowska, Sandra T A Landbeach, GB3 17 1923
Marchant, Joanne St. Ives, GB3 2 77
Neale, Philip J Harston, GB3 7 933

Cited Art Landscape

Patent Info (Count) # Cites Year
 
EGYT GYOGYSZERVEGYESZETI GYAR, 30-38, KERESZTURI UT, H-1106 BUDAPEST, HUNGARY (1)
* 4748023 Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content 50 1984
 
Key Pharmaceuticals, Inc. (1)
* 4587118 Dry sustained release theophylline oral formulation 63 1984
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (4)
* 2005/0192,309 Method of preventing abuse of opioid dosage forms 30 2003
* 2005/0181,046 Tamper-resistant oral opioid agonist formulations 61 2003
* 2005/0095,291 Tamper-resistant oral opioid agonist formulations 70 2003
* 2004/0092,542 Tamper-resistant oral opioid agonist formulations 53 2003
 
Societe de Conseils de Recherches et d'Applications (S.C.R.A.S.) (1)
* 5569467 Process for the preparation of microballs and microballs thus obtained 16 1994
 
ABBOTT LABORATORIES (1)
* 5160742 System for delivering an active substance for sustained release 41 1991
 
Philip Morris USA Inc. (2)
7866324 Cigarette and filter with cellulosic flavor addition 1 2006
* 2006/0272,662 Cigarette and filter with cellulosic flavor addition 16 2006
 
EURO-CELTIQUE S.A. (1)
* 5091189 Controlled release dosage forms having a defined water content 61 1991
 
IPSEN PHARMA S.A.S. (1)
* 5213812 Preparation process of sustained release compositions and the compositions thus obtained 26 1991
 
PURDUE PHARMA L.P. (55)
6696088 Tamper-resistant oral opioid agonist formulations 189 2001
7943173 Pharmaceutical combinations of oxycodone and naloxone 10 2002
7914818 Opioid agonist formulations with releasable and sequestered antagonist 19 2002
* 2003/0157,168 Sequestered antagonist formulations 74 2002
6696066 Opioid agonist/antagonist combinations 188 2002
7842311 Tamper-resistant oral opioid agonist formulations 19 2003
* 2004/0186,121 Tamper-resistant oral opioid agonist formulations 62 2003
7172767 Opioid agonist / antagonist combinations 107 2003
* 2004/0086,561 Opioid agonist / antagonist combinations 0 2003
7842309 Tamper-resistant oral opioid agonist formulations 15 2003
7718192 Tamper-resistant oral opioid agonist formulations 24 2003
7682632 Tamper-resistant oral opioid agonist formulations 24 2003
7658939 Tamper-resistant oral opioid agonist formulations 84 2003
* 2008/0306,104 TAMPER-RESISTANT ORAL OPIOID AGONIST FORMULATIONS 6 2003
9149436 Pharmaceutical product comprising a sequestered agent 0 2004
7384653 Oral dosage form comprising a therapeutic agent and an adverse-effect agent 33 2004
8518925 Opioids for the treatment of the chronic obstructive pulmonary disease (COPD) 6 2005
8465774 Sequestered antagonist formulations 6 2006
* 2008/0167,533 Method and Device for the Assessment of Bowel Function 2 2006
7419686 Opioid agonist/antagonist combinations 66 2006
* 2007/0122,348 Opioid agonist/antagonist combinations 29 2006
7749542 Opioid agonist/antagonist combinations 42 2008
9271940 Immediate release pharmaceutical compositions comprising oxycodone and naloxone 0 2010
8105631 Opioid agonist/antagonist combinations 41 2010
8236351 Tamper-resistant oral opioid agonist formulations 7 2010
8231901 Opioid agonist formulations with releasable and sequestered antagonist 4 2011
8673355 Opioid agonist/antagonist combinations 12 2011
8846090 Matrix for sustained, invariant and independent release of active compounds 14 2012
8518443 Opioid agonist formulations with releasable and sequestered antagonist 6 2012
8357399 Tamper-resistant oral opioid agonist formulations 5 2012
8822487 Opioid agonist/opioid antagonist/acetaminophen combinations 12 2012
8586088 Tamper-resistant oral opioid agonist formulations 3 2012
8758825 Sequestered antagonist formulations 0 2013
8815287 Opiod agonist formulations with releasable and sequestered antagonist 0 2013
8936812 Tamper-resistant oral opioid agonist formulations 1 2013
8846091 Matrix for sustained, invariant and independent release of active compounds 13 2013
RE45822 Oral dosage form comprising a therapeutic agent and an adverse-effect agent 0 2013
9084729 Abuse-resistant controlled-release opioid dosage form 2 2013
8969369 Abuse-resistant controlled-release opioid dosage form 14 2013
9056051 Abuse-resistant controlled-release opioid dosage form 4 2014
9205082 Opioid agonist/antagonist combinations 0 2014
9555000 Pharmaceutical preparation containing oxycodone and naloxone 0 2014
9474750 Opioid agonist/opioid antagonist/acetaminophen combinations 0 2014
9655855 Matrix for sustained, invariant and independent release of active compounds 0 2014
8932630 Opioid agonist/antagonist combinations 2 2014
9456989 Tamper-resistant oral opioid agonist formulations 0 2014
9278073 Tamper-resistant oral opioid agonist formulations 1 2015
9168252 Abuse-resistant controlled-release opioid dosage form 2 2015
9161937 Abuse-resistant controlled-release opioid dosage form 2 2015
9283216 Abuse-resistant controlled-release opioid dosage form 0 2015
9283221 Abuse-resistant controlled-release opioid dosage form 0 2015
9358230 Abuse-resistant controlled-release opioid dosage form 0 2016
9345701 Abuse-resistant controlled-release opioid dosage form 0 2016
9511066 Abuse-resistant controlled-release opioid dosage form 0 2016
9480685 Abuse-resistant controlled-release opioid dosage form 0 2016
 
WYETH HOLDINGS LLC (1)
* 5776489 Controlled release carbonic anhydrase inhibitor containing pharmaceutical compositions from spherical granules in capsule oral dosage unit form 13 1992
 
PFIZER INC. (1)
7682634 Pharmaceutical compositions 6 2009
 
ALPHARMA PHARMACEUTICALS, LLC (7)
8158156 Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist 0 2007
8623418 Pharmaceutical composition 0 2008
7682633 Pharmaceutical composition 18 2009
8877247 Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist 0 2010
8685443 Sequestering subunit and related compositions and methods 0 2010
8685444 Sequestering subunit and related compositions and methods 0 2010
8846104 Pharmaceutical compositions for the deterrence and/or prevention of abuse 0 2012
 
ROCHE DIABETES CARE, INC. (1)
* 5413690 Potentiometric biosensor and the method of its use 360 1993
 
NORDMARK ARZNEIMITTEL GMBH & CO. KG (1)
* 5160469 Manufacture of pellets of xanthine derivatives 2 1990
 
ELITE LABORATORIES INC. (3)
8182836 Abuse-resistant oral dosage forms and method of use thereof 11 2009
8425933 Abuse-resistant oral dosage forms and method of use thereof 10 2009
8703186 Abuse-resistant oral dosage forms and method of use thereof 0 2013
 
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (1)
* 5945125 Controlled release tablet 90 1996
 
F.H. FAULDING & CO. LIMITED (1)
* 5196203 Theophylline dosage form 68 1991
 
American Cyanamid Company (1)
* 5283065 Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form 122 1992
 
LG DISPLAY CO., LTD. (1)
* 2005/0099,572 Liquid crystal display device 0 2003
* Cited By Examiner