Spheroids

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 4844910
SERIAL NO

07122747

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ATTORNEY / AGENT: (SPONSORED)

Importance

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Abstract

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A controlled release pharmaceutical composition comprising a plurality of film coated spheroids, the film coated spheroids comprising a 3-alkylxanthine, a non-water soluble spheronising agent and between 4% and 9% (by weight) water, wherein the in-vitro dissolution rate of the 3-alkylxanthine from the film coated spheroids, when measured by the USP Paddle Method at 100 rpm in 900 ml aqueous buffer (pH 6.5 at 37.degree. C.) is between 7.5% and 25.0% (by wt) release after 1 hour, between 22.5% and 45.0% (by wt) release after 2 hours, between 40.0% and 60.0% (by wt) release after 3 hours, between 50.0% and 75.0% (by wt) release after 4 hours, between 70.0% and 92.5% (by wt) release after 6 hours, and between 80.0% and 100.0% (by wt) release after 8 hours. Preferably the water content is between 4% and 8%, especially between 4% and 7% (by wt) of the film coated spheroid formulation. The preferred 3-alkylxanthine is theophylline (anhydrous or hydrate), whilst the preferred spheronising agent is microcrystalline cellulose.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
EURO-CELTIQUE S.A.LUXEMBOURG95
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURGSTAMFORD, CT0

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Leslie, Stewart T Cambridge, GB3 24 2481
Malkowska, Sandra T A Landbeach, GB3 17 2077
Marchant, Joanne St. Ives, GB3 2 81
Neale, Philip J Harston, GB3 7 977

Cited Art Landscape

Patent Info (Count) # Cites Year
 
EGYT GYOGYSZERVEGYESZETI GYAR, 30-38, KERESZTURI UT, H-1106 BUDAPEST, HUNGARY (1)
* 4748023 Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content 55 1984
 
Key Pharmaceuticals, Inc. (1)
* 4587118 Dry sustained release theophylline oral formulation 66 1984
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (5)
* 2005/0192,309 Method of preventing abuse of opioid dosage forms 34 2003
* 2005/0181,046 Tamper-resistant oral opioid agonist formulations 75 2003
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* 2004/0092,542 Tamper-resistant oral opioid agonist formulations 58 2003
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6696066 Opioid agonist/antagonist combinations 210 2002
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7172767 Opioid agonist / antagonist combinations 123 2003
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9056051 Abuse-resistant controlled-release opioid dosage form 8 2014
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9555000 Pharmaceutical preparation containing oxycodone and naloxone 2 2014
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9168252 Abuse-resistant controlled-release opioid dosage form 4 2015
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9283221 Abuse-resistant controlled-release opioid dosage form 2 2015
9820983 Immediate release pharmaceutical compositions comprising oxycodone and naloxone 0 2016
9358230 Abuse-resistant controlled-release opioid dosage form 2 2016
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9801828 Tamper resistant oral opioid agonist formulations 0 2016
9907793 Pharmaceutical preparation containing oxycodone and naloxone 0 2017
 
WYETH HOLDINGS LLC (1)
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PFIZER INC. (1)
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ALPHARMA PHARMACEUTICALS, LLC (7)
8158156 Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist 4 2007
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F.H. FAULDING & CO. LIMITED (1)
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LG DISPLAY CO., LTD. (1)
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* Cited By Examiner