Spheroids
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Jul 4, 1989
Grant Date -
N/A
app pub date -
Nov 19, 1987
filing date -
Dec 2, 1986
priority date (Note) -
Expired
status (Latency Note)
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Importance

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Forward Citations
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Abstract
A controlled release pharmaceutical composition comprising a plurality of film coated spheroids, the film coated spheroids comprising a 3-alkylxanthine, a non-water soluble spheronising agent and between 4% and 9% (by weight) water, wherein the in-vitro dissolution rate of the 3-alkylxanthine from the film coated spheroids, when measured by the USP Paddle Method at 100 rpm in 900 ml aqueous buffer (pH 6.5 at 37.degree. C.) is between 7.5% and 25.0% (by wt) release after 1 hour, between 22.5% and 45.0% (by wt) release after 2 hours, between 40.0% and 60.0% (by wt) release after 3 hours, between 50.0% and 75.0% (by wt) release after 4 hours, between 70.0% and 92.5% (by wt) release after 6 hours, and between 80.0% and 100.0% (by wt) release after 8 hours. Preferably the water content is between 4% and 8%, especially between 4% and 7% (by wt) of the film coated spheroid formulation. The preferred 3-alkylxanthine is theophylline (anhydrous or hydrate), whilst the preferred spheronising agent is microcrystalline cellulose.

First Claim
Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | Total Patents |
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EURO-CELTIQUE S.A. | LUXEMBOURG | 95 |
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURG | STAMFORD, CT | 0 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
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Leslie, Stewart T | Cambridge, GB3 | 24 | 2481 |
Malkowska, Sandra T A | Landbeach, GB3 | 17 | 2077 |
Marchant, Joanne | St. Ives, GB3 | 2 | 81 |
Neale, Philip J | Harston, GB3 | 7 | 977 |
Cited Art Landscape
Patent Info | (Count) | # Cites | Year |
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* 4748023 Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content | 55 | 1984 | |
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* 4587118 Dry sustained release theophylline oral formulation | 66 | 1984 |
Patent Citation Ranking
Forward Cite Landscape
Patent Info | (Count) | # Cites | Year |
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* 2005/0192,309 Method of preventing abuse of opioid dosage forms | 34 | 2003 | |
* 2005/0181,046 Tamper-resistant oral opioid agonist formulations | 75 | 2003 | |
* 2005/0095,291 Tamper-resistant oral opioid agonist formulations | 83 | 2003 | |
* 2004/0092,542 Tamper-resistant oral opioid agonist formulations | 58 | 2003 | |
9949930 Opioid agonist formulations with releasable and sequestered antagonist | 0 | 2014 | |
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* 5569467 Process for the preparation of microballs and microballs thus obtained | 16 | 1994 | |
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* 5160742 System for delivering an active substance for sustained release | 46 | 1991 | |
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7866324 Cigarette and filter with cellulosic flavor addition | 1 | 2006 | |
* 2006/0272,662 Cigarette and filter with cellulosic flavor addition | 17 | 2006 | |
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* 5091189 Controlled release dosage forms having a defined water content | 65 | 1991 | |
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* 5213812 Preparation process of sustained release compositions and the compositions thus obtained | 29 | 1991 | |
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6696088 Tamper-resistant oral opioid agonist formulations | 241 | 2001 | |
7943173 Pharmaceutical combinations of oxycodone and naloxone | 15 | 2002 | |
7914818 Opioid agonist formulations with releasable and sequestered antagonist | 29 | 2002 | |
* 2003/0157,168 Sequestered antagonist formulations | 85 | 2002 | |
6696066 Opioid agonist/antagonist combinations | 210 | 2002 | |
7842311 Tamper-resistant oral opioid agonist formulations | 32 | 2003 | |
* 2004/0186,121 Tamper-resistant oral opioid agonist formulations | 68 | 2003 | |
7172767 Opioid agonist / antagonist combinations | 123 | 2003 | |
* 2004/0086,561 Opioid agonist / antagonist combinations | 2 | 2003 | |
7842309 Tamper-resistant oral opioid agonist formulations | 19 | 2003 | |
7718192 Tamper-resistant oral opioid agonist formulations | 30 | 2003 | |
7682632 Tamper-resistant oral opioid agonist formulations | 30 | 2003 | |
7658939 Tamper-resistant oral opioid agonist formulations | 112 | 2003 | |
* 2008/0306,104 TAMPER-RESISTANT ORAL OPIOID AGONIST FORMULATIONS | 6 | 2003 | |
9149436 Pharmaceutical product comprising a sequestered agent | 2 | 2004 | |
7384653 Oral dosage form comprising a therapeutic agent and an adverse-effect agent | 38 | 2004 | |
8518925 Opioids for the treatment of the chronic obstructive pulmonary disease (COPD) | 6 | 2005 | |
8465774 Sequestered antagonist formulations | 17 | 2006 | |
* 2008/0167,533 Method and Device for the Assessment of Bowel Function | 3 | 2006 | |
7419686 Opioid agonist/antagonist combinations | 76 | 2006 | |
* 2007/0122,348 Opioid agonist/antagonist combinations | 35 | 2006 | |
7749542 Opioid agonist/antagonist combinations | 51 | 2008 | |
9271940 Immediate release pharmaceutical compositions comprising oxycodone and naloxone | 0 | 2010 | |
8105631 Opioid agonist/antagonist combinations | 50 | 2010 | |
8236351 Tamper-resistant oral opioid agonist formulations | 11 | 2010 | |
8231901 Opioid agonist formulations with releasable and sequestered antagonist | 10 | 2011 | |
8673355 Opioid agonist/antagonist combinations | 23 | 2011 | |
8846090 Matrix for sustained, invariant and independent release of active compounds | 25 | 2012 | |
8518443 Opioid agonist formulations with releasable and sequestered antagonist | 13 | 2012 | |
8357399 Tamper-resistant oral opioid agonist formulations | 9 | 2012 | |
8822487 Opioid agonist/opioid antagonist/acetaminophen combinations | 23 | 2012 | |
8586088 Tamper-resistant oral opioid agonist formulations | 7 | 2012 | |
8758825 Sequestered antagonist formulations | 2 | 2013 | |
8815287 Opiod agonist formulations with releasable and sequestered antagonist | 4 | 2013 | |
8936812 Tamper-resistant oral opioid agonist formulations | 3 | 2013 | |
8846091 Matrix for sustained, invariant and independent release of active compounds | 24 | 2013 | |
RE45822 Oral dosage form comprising a therapeutic agent and an adverse-effect agent | 1 | 2013 | |
9084729 Abuse-resistant controlled-release opioid dosage form | 6 | 2013 | |
8969369 Abuse-resistant controlled-release opioid dosage form | 24 | 2013 | |
9056051 Abuse-resistant controlled-release opioid dosage form | 8 | 2014 | |
9205082 Opioid agonist/antagonist combinations | 4 | 2014 | |
9555000 Pharmaceutical preparation containing oxycodone and naloxone | 2 | 2014 | |
9474750 Opioid agonist/opioid antagonist/acetaminophen combinations | 2 | 2014 | |
9655855 Matrix for sustained, invariant and independent release of active compounds | 2 | 2014 | |
8932630 Opioid agonist/antagonist combinations | 8 | 2014 | |
9456989 Tamper-resistant oral opioid agonist formulations | 0 | 2014 | |
9278073 Tamper-resistant oral opioid agonist formulations | 1 | 2015 | |
9168252 Abuse-resistant controlled-release opioid dosage form | 4 | 2015 | |
9161937 Abuse-resistant controlled-release opioid dosage form | 6 | 2015 | |
9283216 Abuse-resistant controlled-release opioid dosage form | 2 | 2015 | |
9283221 Abuse-resistant controlled-release opioid dosage form | 2 | 2015 | |
9820983 Immediate release pharmaceutical compositions comprising oxycodone and naloxone | 0 | 2016 | |
9358230 Abuse-resistant controlled-release opioid dosage form | 2 | 2016 | |
9345701 Abuse-resistant controlled-release opioid dosage form | 2 | 2016 | |
9511066 Abuse-resistant controlled-release opioid dosage form | 2 | 2016 | |
9480685 Abuse-resistant controlled-release opioid dosage form | 2 | 2016 | |
9801828 Tamper resistant oral opioid agonist formulations | 0 | 2016 | |
9907793 Pharmaceutical preparation containing oxycodone and naloxone | 0 | 2017 | |
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* 5776489 Controlled release carbonic anhydrase inhibitor containing pharmaceutical compositions from spherical granules in capsule oral dosage unit form | 13 | 1992 | |
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7682634 Pharmaceutical compositions | 9 | 2009 | |
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8158156 Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist | 4 | 2007 | |
8623418 Pharmaceutical composition | 4 | 2008 | |
7682633 Pharmaceutical composition | 24 | 2009 | |
8877247 Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist | 3 | 2010 | |
8685443 Sequestering subunit and related compositions and methods | 2 | 2010 | |
8685444 Sequestering subunit and related compositions and methods | 2 | 2010 | |
8846104 Pharmaceutical compositions for the deterrence and/or prevention of abuse | 3 | 2012 | |
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* 5413690 Potentiometric biosensor and the method of its use | 373 | 1993 | |
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* 5160469 Manufacture of pellets of xanthine derivatives | 2 | 1990 | |
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8182836 Abuse-resistant oral dosage forms and method of use thereof | 15 | 2009 | |
8425933 Abuse-resistant oral dosage forms and method of use thereof | 15 | 2009 | |
8703186 Abuse-resistant oral dosage forms and method of use thereof | 3 | 2013 | |
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* 5945125 Controlled release tablet | 112 | 1996 | |
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* 5196203 Theophylline dosage form | 69 | 1991 | |
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* 5283065 Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form | 133 | 1992 | |
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* 2005/0099,572 Liquid crystal display device | 0 | 2003 |
Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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Fee | Large entity fee | small entity fee | micro entity fee |
---|---|---|---|
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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