US Patent No: 4,844,910

Number of patents in Portfolio can not be more than 2000

Spheroids

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Abstract

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A controlled release pharmaceutical composition comprising a plurality of film coated spheroids, the film coated spheroids comprising a 3-alkylxanthine, a non-water soluble spheronising agent and between 4% and 9% (by weight) water, wherein the in-vitro dissolution rate of the 3-alkylxanthine from the film coated spheroids, when measured by the USP Paddle Method at 100 rpm in 900 ml aqueous buffer (pH 6.5 at 37.degree. C.) is between 7.5% and 25.0% (by wt) release after 1 hour, between 22.5% and 45.0% (by wt) release after 2 hours, between 40.0% and 60.0% (by wt) release after 3 hours, between 50.0% and 75.0% (by wt) release after 4 hours, between 70.0% and 92.5% (by wt) release after 6 hours, and between 80.0% and 100.0% (by wt) release after 8 hours. Preferably the water content is between 4% and 8%, especially between 4% and 7% (by wt) of the film coated spheroid formulation. The preferred 3-alkylxanthine is theophylline (anhydrous or hydrate), whilst the preferred spheronising agent is microcrystalline cellulose.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
EURO-CELTIQUE S.A.LUXEMBOURG162
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURGSTAMFORD, CT5

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Leslie, Stewart T Cambridge, GB2 24 1369
Malkowska, Sandra T A Cambridgeshire, GB2 17 1183
Marchant, Joanne St. Ives, GB3 2 49
Neale, Philip J Cambridge, GB 7 633

Cited Art Landscape

Patent Info (Count) # Cites Year
 
EGYT GYOGYSZERVEGYESZETI GYAR, 30-38, KERESZTURI UT, H-1106 BUDAPEST, HUNGARY (1)
4,748,023 Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content 39 1984
 
Key Pharmaceuticals, Inc. (1)
4,587,118 Dry sustained release theophylline oral formulation 48 1984

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
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7,842,311 Tamper-resistant oral opioid agonist formulations 5 2003
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7,718,192 Tamper-resistant oral opioid agonist formulations 11 2003
7,682,632 Tamper-resistant oral opioid agonist formulations 11 2003
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7,384,653 Oral dosage form comprising a therapeutic agent and an adverse-effect agent 14 2004
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8,105,631 Opioid agonist/antagonist combinations 2 2010
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8,231,901 Opioid agonist formulations with releasable and sequestered antagonist 0 2011
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8,518,443 Opioid agonist formulations with releasable and sequestered antagonist 0 2012
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8,158,156 Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist 0 2007
8,623,418 Pharmaceutical composition 0 2008
7,682,633 Pharmaceutical composition 5 2009
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8,685,444 Sequestering subunit and related compositions and methods 0 2010
 
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8,182,836 Abuse-resistant oral dosage forms and method of use thereof 0 2009
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ABBOTT LABORATORIES (1)
5,160,742 System for delivering an active substance for sustained release 34 1991
 
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5,283,065 Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form 77 1992
 
EURO-CELTIQUE S.A. (1)
5,091,189 Controlled release dosage forms having a defined water content 35 1991
 
F.H. FAULDING & CO. LIMITED (1)
5,196,203 Theophylline dosage form 42 1991
 
NORDMARK ARZNEIMITTEL GMBH & CO. KG (1)
5,160,469 Manufacture of pellets of xanthine derivatives 2 1990
 
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TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (1)
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5,776,489 Controlled release carbonic anhydrase inhibitor containing pharmaceutical compositions from spherical granules in capsule oral dosage unit form 11 1992

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