US Patent No: 4,844,910

Number of patents in Portfolio can not be more than 2000

Spheroids

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Abstract

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A controlled release pharmaceutical composition comprising a plurality of film coated spheroids, the film coated spheroids comprising a 3-alkylxanthine, a non-water soluble spheronising agent and between 4% and 9% (by weight) water, wherein the in-vitro dissolution rate of the 3-alkylxanthine from the film coated spheroids, when measured by the USP Paddle Method at 100 rpm in 900 ml aqueous buffer (pH 6.5 at 37.degree. C.) is between 7.5% and 25.0% (by wt) release after 1 hour, between 22.5% and 45.0% (by wt) release after 2 hours, between 40.0% and 60.0% (by wt) release after 3 hours, between 50.0% and 75.0% (by wt) release after 4 hours, between 70.0% and 92.5% (by wt) release after 6 hours, and between 80.0% and 100.0% (by wt) release after 8 hours. Preferably the water content is between 4% and 8%, especially between 4% and 7% (by wt) of the film coated spheroid formulation. The preferred 3-alkylxanthine is theophylline (anhydrous or hydrate), whilst the preferred spheronising agent is microcrystalline cellulose.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
EURO-CELTIQUE S.A.LUXEMBOURG83
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURGSTAMFORD, CT0

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Leslie, Stewart T Cambridge, GB2 24 1529
Malkowska, Sandra T A Cambridgeshire, GB2 17 1318
Marchant, Joanne St. Ives, GB3 2 57
Neale, Philip J Cambridge, GB 7 698

Cited Art Landscape

Patent Info (Count) # Cites Year
 
EGYT GYOGYSZERVEGYESZETI GYAR, 30-38, KERESZTURI UT, H-1106 BUDAPEST, HUNGARY (1)
* 4,748,023 Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content 42 1984
 
Key Pharmaceuticals, Inc. (1)
* 4,587,118 Dry sustained release theophylline oral formulation 50 1984
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
PURDUE PHARMA L.P. (29)
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7,943,173 Pharmaceutical combinations of oxycodone and naloxone 2 2002
7,914,818 Opioid agonist formulations with releasable and sequestered antagonist 5 2002
6,696,066 Opioid agonist/antagonist combinations 92 2002
7,842,311 Tamper-resistant oral opioid agonist formulations 5 2003
7,172,767 Opioid agonist / antagonist combinations 53 2003
7,842,309 Tamper-resistant oral opioid agonist formulations 4 2003
7,718,192 Tamper-resistant oral opioid agonist formulations 12 2003
7,682,632 Tamper-resistant oral opioid agonist formulations 12 2003
7,658,939 Tamper-resistant oral opioid agonist formulations 15 2003
7,384,653 Oral dosage form comprising a therapeutic agent and an adverse-effect agent 19 2004
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8,465,774 Sequestered antagonist formulations 0 2006
7,419,686 Opioid agonist/antagonist combinations 29 2006
7,749,542 Opioid agonist/antagonist combinations 11 2008
8,105,631 Opioid agonist/antagonist combinations 10 2010
8,236,351 Tamper-resistant oral opioid agonist formulations 1 2010
8,231,901 Opioid agonist formulations with releasable and sequestered antagonist 0 2011
8,673,355 Opioid agonist/antagonist combinations 0 2011
8,846,090 Matrix for sustained, invariant and independent release of active compounds 0 2012
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8,758,825 Sequestered antagonist formulations 0 2013
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8,936,812 Tamper-resistant oral opioid agonist formulations 0 2013
8,846,091 Matrix for sustained, invariant and independent release of active compounds 0 2013
8,932,630 Opioid agonist/antagonist combinations 0 2014
 
ALPHARMA PHARMACEUTICALS, LLC (8)
8,158,156 Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist 0 2007
8,623,418 Pharmaceutical composition 0 2008
7,682,633 Pharmaceutical composition 9 2009
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ABBOTT LABORATORIES (1)
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American Cyanamid Company (1)
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EURO-CELTIQUE S.A. (1)
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F.H. FAULDING & CO. LIMITED (1)
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WYETH HOLDINGS LLC (1)
* 5,776,489 Controlled release carbonic anhydrase inhibitor containing pharmaceutical compositions from spherical granules in capsule oral dosage unit form 11 1992
* Cited By Examiner