Biologically active B-chain homodimers
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United States of America Patent
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Jul 4, 1989
Issued Date -
N/A
app pub date -
Dec 15, 1986
filing date -
Feb 25, 1985
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Dimeric proteins having substantially the same biological activity as PDGF are disclosed. More specifically, the protein may have two substantially identical polypeptide chains, each of the chains being substantially homologous to the B-chain of PDGF. Alternatively, the protein may have two polypeptide chains that are substantially identical to the B-chain of PDGF. In addition, proteins comprising polypeptides that are variants or derivatives of the B-chain of PDGF are also disclosed. Therapeutic compositions containing these proteins and methods for enhancing the wound-healing process in warm-blooded animals are also disclosed.
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