2-substituted -1,4-dihydropyridines and pharmaceutical compositions containing them
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United States of America Patent
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Jul 4, 1989
Grant Date -
N/A
app pub date -
Jul 25, 1986
filing date -
Aug 19, 1985
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Compounds of formula I ##STR1## wherein R is hydrogen or lower alkyl; R.sub.1 is acetyl, benzoyl, cyano, nitro, carboxy, alkoxycarbonyl or aminocarbonyl groups; R.sub.2 is an optionally substituted aryl or hetaryl residue; R.sub.3 is a carboxy or alkoxycarbonyl group; A is a cyclopropyl group or a group of formula --CH.dbd.CH-- and R.sub.4 is a phenyl or heteroaryl group, optionally mono, di or tri-substituted, are useful in radical scavenging therapy.
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