Method of preparing ketoprofen
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United States of America Patent
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Jul 4, 1989
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N/A
app pub date -
Jul 29, 1988
filing date -
Aug 6, 1987
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Expired
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Abstract
A method of preparing ketoprofen by reacting aniline with a halide of an alpha-halogen propionic acid, benzylation of 3-methyl-2-indolinone, alkaline hydrolysis of 5-benzyl-3-methyl-2-indolinone, deamination of 2-(3-benzyl-6-aminophenyl)propionic acid and oxidation of 2-(3-benzylphenyl)propionic acid.
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