Signal amplification in an assay employing a piezoelectric oscillator
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United States of America Patent
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Jul 11, 1989
Grant Date -
N/A
app pub date -
Jun 18, 1987
filing date -
Jun 18, 1987
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method for detecting a first member of a specific binding pair in a sample, the first member being capable of forming a complex with a second member of the specific binding pair, includes immobilizing the second member on a surface of a piezoelectric oscillator, determining a first vibrational frequency of the oscillator on which the second member has been immobilized, contacting the surface of the oscillator on which the second member has been immobilized with the sample under conditions permitting formation of the complex, and with a particle under conditions permitting binding of the particle with the first member, mass coupling the bound particle with the oscillator, and determining a second vibrational frequency of the oscillator with which the particle has been mass coupled, the difference between the first vibrational frequency and the second vibrational frequency providing a measure of the quantity of the first member in the sample.
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