US Patent No: 4,849,405

Number of patents in Portfolio can not be more than 2000

Oral insulin and a method of making the same

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Abstract

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The present invention provides for a composition of matter useful as an oral dosage form of insulin based upon a two phase liquid aqueous system in which insulin component or components are incorporated. The invention also provides for a method of preparing the oral dosage form of insulin, as well as a further process whereby sustained release dosage forms of oral insulin are produced. The oral form of insulin eliminates or reduces the need to use injection as a mode of administering insulin.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
QUIXOTE CORPORATIONDEERFIELD, IL21

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ecanow, Bernard Wilmette, IL 17 584

Cited Art Landscape

Patent Info (Count) # Cites Year
 
SYNTHETIC BLOOD CORPORATION (2)
4,343,797 Synthetic whole blood and a method of making the same 15 1981
4,439,424 Synthetic whole blood 14 1982
 
BRITISH TECHNOLOGY GROUP LIMITED (1)
4,448,765 Liposomes and their use in treating human or other mammalian patients 58 1979
 
Sandoz, Inc. (1)
4,356,167 Liposome drug delivery systems 82 1981
 
The Procter & Gamble Company (1)
4,394,372 Process for making lipid membrane structures 56 1982

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
BIOCON LIMITED (33)
5,681,811 Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same 99 1995
6,191,105 Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin 51 1997
6,703,381 Methods for delivery therapeutic compounds across the blood-brain barrier 16 1998
6,309,633 Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same 104 1999
6,956,051 Enkephalin conjugates 0 1999
6,858,580 Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 27 2001
6,835,802 Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties 10 2001
6,828,297 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 10 2001
6,828,305 Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 5 2001
6,713,452 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 11 2001
6,913,903 Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 4 2001
7,060,675 Methods of treating diabetes mellitus 7 2002
6,867,183 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 11 2002
6,770,625 Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith 9 2002
7,713,932 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7,608,584 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7,196,059 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 3 2003
7,166,571 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 2 2003
7,030,082 Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith 4 2003
7,312,192 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 0 2003
7,601,688 Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus 1 2003
6,930,090 Methods of activating a receptor using amphiphilic drug-oligomer conjugates 6 2003
7,030,084 Drug-oligomer conjugates with polyethylene glycol components 10 2004
7,084,121 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 0 2004
7,084,114 Mixtures of insulin drug-oligomer comprising polyalkylene glycol 8 2004
7,611,864 Proinsulin polypeptide-oligomer conjugates 0 2004
7,875,700 Cation complexes of insulin compound conjugates, formulation and uses thereof 1 2005
7,872,095 Insulin-oligomer conjugates, formulations and uses thereof 0 2005
7,423,014 Insulin conjugates for treating diabetes mellitus 2 2005
7,470,663 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 0 2006
7,381,702 Methods of treating diabetes mellitus 0 2006
8,563,685 Fatty acid formulations and oral delivery of proteins and peptides, and uses thereof 0 2009
8,030,269 Calcitonin drug-oligomer conjugates, and uses thereof 0 2009
 
ASTRA AKTLEBOLAG (2)
6,932,962 Aerosol drug formulations containing hydrofluoroalkanes and alkyl saccharides 15 1995
6,524,557 Aerosol formulations of peptides and proteins 20 1996
 
Generex Pharmaceuticals Incorporated (2)
6,017,545 Mixed micellar delivery system and method of preparation 39 1998
6,221,378 Mixed micellar delivery system and method of preparation 28 1999
 
LAI VENTURES, INC. (2)
5,359,030 Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same 135 1993
5,438,040 Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same 88 1994
 
INSTITUT FRANCAIS DU PETROLE (1)
7,605,123 Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof 1 2005
 
NOBEX CORPORATION (1)
6,943,148 Methods for delivering therapeutics across blood-barrier and for altering receptor binding affinity 4 1999
 
PROTEIN DELIVERY INC. (1)
7,169,889 Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin 1 2000
 
RIEVELEY, CHERYL ANNE (1)
6,153,632 Method and composition for the treatment of diabetes 47 1997
 
Other [Check patent profile for assignment information] (1)
6,291,495 Method and composition for the treatment of diabetes 9 2000

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