Oral insulin and a method of making the same

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United States of America Patent

PATENT NO 4849405
SERIAL NO

06835550

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Abstract

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The present invention provides for a composition of matter useful as an oral dosage form of insulin based upon a two phase liquid aqueous system in which insulin component or components are incorporated. The invention also provides for a method of preparing the oral dosage form of insulin, as well as a further process whereby sustained release dosage forms of oral insulin are produced. The oral form of insulin eliminates or reduces the need to use injection as a mode of administering insulin.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
QUIXOTE CORPORATIONDEERFIELD, IL2

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ecanow, Bernard Wilmette, IL 17 677

Cited Art Landscape

Patent Info (Count) # Cites Year
 
SYNTHETIC BLOOD CORPORATION (2)
* 4343797 Synthetic whole blood and a method of making the same 15 1981
* 4439424 Synthetic whole blood 14 1982
 
The Procter & Gamble Company (1)
* 4394372 Process for making lipid membrane structures 63 1982
 
SANDOZ INC (1)
* 4356167 Liposome drug delivery systems 102 1981
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
6291495 Method and composition for the treatment of diabetes 11 2000
 
RIEVELEY, CHERYL ANNE (1)
* 6153632 Method and composition for the treatment of diabetes 58 1997
 
Generex Pharmaceuticals Incorporated (2)
* 6017545 Mixed micellar delivery system and method of preparation 49 1998
6221378 Mixed micellar delivery system and method of preparation 37 1999
 
LAI VENTURES, INC. (2)
* 5359030 Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same 178 1993
* 5438040 Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same 100 1994
 
BIOCON LIMITED (51)
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6191105 Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin 59 1997
6703381 Methods for delivery therapeutic compounds across the blood-brain barrier 32 1998
6309633 Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same 116 1999
6956051 Enkephalin conjugates 0 1999
6858580 Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 42 2001
6835802 Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties 15 2001
6828297 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 14 2001
6828305 Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 5 2001
6713452 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 11 2001
* 2003/0228,275 Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 4 2001
* 2003/0060,606 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 4 2001
* 2003/0027,995 Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 4 2001
* 2003/0004,304 Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties 4 2001
6913903 Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 5 2001
7060675 Methods of treating diabetes mellitus 11 2002
* 2003/0050,228 Methods of treating diabetes mellitus 6 2002
6867183 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 19 2002
6770625 Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith 16 2002
* 2003/0069,170 Pharmaceutical compositions of drug-oligomer conjugates and methods of treating diseases therewith 9 2002
7713932 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7608584 Calcitonin drug-oligomer conjugates, and uses thereof 0 2002
7196059 Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith 3 2003
7166571 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 2 2003
7030082 Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith 9 2003
* 2004/0017,387 Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith 4 2003
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* 2003/0228,652 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 2 2003
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6930090 Methods of activating a receptor using amphiphilic drug-oligomer conjugates 15 2003
* 2004/0110,735 Methods of activating receptor using amphiphilic drug-oligomer conjugates 0 2003
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7030084 Drug-oligomer conjugates with polyethylene glycol components 29 2004
7084121 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 0 2004
7084114 Mixtures of insulin drug-oligomer comprising polyalkylene glycol 9 2004
7611864 Proinsulin polypeptide-oligomer conjugates 0 2004
* 2005/0080,001 Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same 3 2004
7875700 Cation complexes of insulin compound conjugates, formulation and uses thereof 5 2005
7872095 Insulin-oligomer conjugates, formulations and uses thereof 4 2005
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* 2006/0019,874 Cation complexes of insulin compund conjugates, formulation and uses thereof 35 2005
7423014 Insulin conjugates for treating diabetes mellitus 12 2005
* 2006/0100,137 Methods of treating diabetes mellitus 0 2005
7470663 Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same 5 2006
7381702 Methods of treating diabetes mellitus 0 2006
9241908 Orally administrable solid pharmaceutical composition and a process thereof 0 2008
8563685 Fatty acid formulations and oral delivery of proteins and peptides, and uses thereof 0 2009
8030269 Calcitonin drug-oligomer conjugates, and uses thereof 0 2009
9102758 Insulin-oligomer conjugates, formulations and uses thereof 0 2011
9101596 Cation complexes of insulin compound conjugates, formulations and uses thereof 0 2011
 
PROTEIN DELIVERY INC. (1)
7169889 Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin 1 2000
 
NOBEX CORPORATION (1)
6943148 Methods for delivering therapeutics across blood-barrier and for altering receptor binding affinity 5 1999
 
INSTITUT FRANCAIS DU PETROLE (1)
7605123 Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof 15 2005
 
MOCHIDA PHARMACEUTICAL CO., LTD. (1)
9486433 Compositions and methods for treating non-alcoholic steatohepatitis 0 2012
 
ASTRA AKTLEBOLAG (2)
6932962 Aerosol drug formulations containing hydrofluoroalkanes and alkyl saccharides 23 1995
6524557 Aerosol formulations of peptides and proteins 40 1996
* Cited By Examiner