Substitute for human blood and a method of making the same
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United States of America Patent
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Aug 1, 1989
Issued Date -
N/A
app pub date -
Apr 15, 1988
filing date -
Apr 27, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The method of this invention yields a two phase liquid aqueous system which replicates the two phase heterogeneous physico-chemical system of naturally securing whole human blood. The method produces: (1) a composition of matter which comprises an oxygen transport solution; (2) when pyridoxalated-polymerized hemoglobin and other specific additives are incorporated, said composition comprises a synthetic blood useful as a physiological substitute for human blood; and (3) when said blood substitute is processed further, yields a microencapsulated composition with time released characteristics that can transport oxygen. The invention overcomes the obstacles that have prevented the use of pyridoxalated-polymerized hemoglobin and other forms of modified hemoglobin in the preparation of oxygen transport solutions.
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