Method for preserving liposomes
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United States of America Patent
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-
Aug 15, 1989
Issued Date -
N/A
app pub date -
May 21, 1987
filing date -
Jan 11, 1985
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method for preserving liposomes includes freeze-drying liposomes most preferably having an average size of about 50 nm to 100 nm with a disaccharide preserving agent being present both internally (with the encapsulated liposomal contents) and externally. The disaccharide component is in a weight ratio with respect to the lipid component of from at least about 0.1:1 to not greater than about 4:1 and is preferably trehalose. When the lyophilizates are reconstituted by rehydration, the resultant liposomes can retain up to 100% of the originally encapsulated contents.
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