Temperature control apparatus

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 4865986
SERIAL NO

07254255

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

Apparatus is disclosed for controlling the heating and cooling of a plurality of upright containers containing a mixture used for performing gene amplification. The apparatus includes a support rack comprising aluminum blocks which is partially submerged in a thermally conductive fluid such that at least the lower portions of the containers are submerged in the fluid with the upper portions engaging the aluminum blocks for efficient heat transfer. Heaters are disposed within the aluminum block for heating the block and a plurality of thermoelectric cooling cells are used to cool the block. A programmable microprocessor is used for controlling the heating and cooling cycles, thereby allowing repetitive heating and cooling of the mixture to produce the copies of the genetic material sought to be copied. A cam separates the support rack from the cooling cells during the heating portion of the process.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
Coy CorporationANN ARBOR, MI0
Coy Laboratory Products, Inc.ANN ARBOR, MI1

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Coy, Richard A Grass Lake, MI 3 187
Waycaster, Roy A Tecumseh, MI 3 206

Cited Art Landscape

Patent Info (Count) # Cites Year
 
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (1)
* 4711851 Test apparatus for determining a metabolic characteristic of microorganisms 37 1984
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (4)
* 5819842 Method and apparatus for temperature control of multiple samples 192 1995
* 2005/0032,198 Method for rapid thermal cycling of biological samples 3 2004
* 2006/0024,204 Well plate sealing apparatus and method 1 2004
* 2006/0029,965 System for fluorescence monitoring 10 2005
 
BECEEM COMMUNICATIONS, INC. (15)
9506943 Aliquotter system and workflow 0 2012
9482684 Centrifuge system and workflow 0 2012
9446418 Robotic arm 0 2012
9046506 Specimen container detection 0 2012
8973736 Magnetic damping for specimen transport system 5 2012
9519000 Reagent cartridge 0 2013
9285382 Reaction vessel 0 2013
9274132 Assay cartridge with reaction well 3 2013
9140715 System and method for controlling thermal cycler modules 2 2013
9046455 System and method including multiple processing lanes executing processing protocols 0 2013
8996320 System and method including analytical units 0 2013
8962308 System and method including thermal cycler modules 0 2013
8956570 System and method including analytical units 0 2013
8932541 Pipettor including compliant coupling 0 2013
8840848 System and method including analytical units 1 2013
 
BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE (1)
* 5270183 Device and method for the automated cycling of solutions between two or more temperatures 146 1991
 
QGENE BIOTECHNOLOGY INC. (1)
* 2003/0211,595 Rack for handling polymerase chain reaction tubes 3 2002
 
NEKTAR THERAPEUTICS (1)
* 7578976 Sleeve reaction chamber system 5 2000
 
SAMSUNG ELECTRONICS CO., LTD. (1)
8663976 Polymerase chain reaction apparatus 4 2011
 
ARKRAY, INC. (2)
* 9101937 Precise temperature controlling unit and method thereof 0 2010
* 2012/0247,725 Temperature Controlling Unit and Temperature Controlling Method 0 2010
 
FREESLATE, INC. (17)
6548026 Parallel reactor with internal sensing and method of using same 62 1998
6306658 Parallel reactor with internal sensing 153 1998
6489168 Analysis and control of parallel chemical reactions 84 1999
6455316 Parallel reactor with internal sensing and method of using same 48 2000
6890492 Parallel reactor with internal sensing and method of using same 8 2000
6864092 Parallel reactor with internal sensing and method of using same 6 2000
6787112 Parallel reactor with internal sensing and method of using same 6 2000
6727096 Analysis and control of parallel chemical reactions 14 2000
6759014 Apparatus and methods for parallel processing of multiple reaction mixtures 25 2001
* 2001/0034,067 Apparatus and methods for parallel processing of multiple reaction mixtures 1 2001
7288229 Parallel reactor with sensing of internal properties 24 2001
6994827 Parallel semicontinuous or continuous reactors 44 2001
6913934 Apparatus and methods for parallel processing of multiple reaction mixtures 8 2002
* 2002/0110,493 Apparatus and methods for parallel processing of multiple reaction mixtures 1 2002
6818183 Multi-temperature modular reactor and method of using same 23 2002
6924149 Parallel reactor with internal sensing and method of using same 8 2002
* 2004/0241,875 Apparatus and methods for parallel processing of multiple reaction mixtures 3 2004
 
GROHMANN ENGINEERING GMBH (3)
7159740 Method and apparatus for parallel dispensing of defined volumes of solid particles 8 2002
* 2003/0124,735 Method and apparatus for parallel dispensing of defined volumes of solid particles 10 2002
* 2003/0111,494 Method and apparatus for high-throughput sample handling process line 21 2002
 
EPPENDORF AG (2)
* 6767512 Temperature-regulating block with temperature-regulating devices 21 1998
* 2004/0258,568 Thermostated block with heat-regulating devices 5 2004
 
HITACHI, LTD. (2)
* 5133936 Constant-temperature air type automatic analysis apparatus 10 1991
* 6251659 Biological sample treating apparatus 4 1999
 
Applied Chemical & Engineering Systems, Inc. (1)
* 6558947 Thermal cycler 60 2000
 
VENTANA MEDICAL SYSTEMS, INC. (23)
6296809 Automated molecular pathology apparatus having independent slide heaters 183 1999
* 7396508 Automated molecular pathology apparatus having independent slide heaters 53 2000
6582962 Automated molecular pathology apparatus having independent slide heaters 101 2000
6855559 Removal of embedding media from biological samples and cell conditioning on automated staining instruments 81 2000
6855552 Automated immunohistochemical and in situ hybridization assay formulations 28 2001
6544798 Removal of embedding media from biological samples and cell conditioning on automated staining instruments 113 2001
7425306 Slide heater 12 2001
7550298 Automated immunohistochemical and in situ hybridization assay formulations 4 2002
7270785 Automated molecular pathology apparatus having fixed slide platforms 33 2002
7067325 Removal of embedding media from biological samples and cell conditioning on automated staining instruments 20 2002
7410753 Removal of embedding media from biological samples and cell conditioning on automated staining instruments 11 2003
* 2004/0121,485 Removal of embedding media from biological samples and cell conditioning on automated staining instruments 3 2003
7303725 Automated high volume slide staining system 55 2003
7378055 Automated molecular pathology apparatus having fixed slide platforms 50 2003
* 2004/0052,685 Automated molecular pathology apparatus having independent slide heaters 24 2003
7615371 Method and apparatus for treating a biological sample with a liquid reagent 9 2004
7468161 Automated high volume slide processing system 35 2005
8663991 Automated high volume slide processing system 1 2005
7404927 Automated molecular pathology apparatus having fixed slide platforms 31 2005
* 2006/0252,025 Low temperature deparaffinization 14 2005
8048373 Automated high volume slide staining system 4 2007
* 2009/0253,592 METHOD AND APPARATUS FOR TREATING A BIOLOGICAL SAMPLE WITH A LIQUID REAGENT 1 2009
9528918 Automated high volume slide processing system 0 2013
 
METTLER-TOLEDO AUTOCHEM, INC. (1)
* 6086831 Modular reaction block assembly with thermoelectric cooling and heating 29 1998
 
UNIVERSITY OF UTAH (12)
* 5455175 Rapid thermal cycling device 152 1994
7081226 System and method for fluorescence monitoring 47 1997
6174670 Monitoring amplification of DNA during PCR 309 1997
* 5935522 On-line DNA analysis system with rapid thermal cycling 50 1997
6787338 Method for rapid thermal cycling of biological samples 48 1998
6245514 Fluorescent donor-acceptor pair with low spectral overlap 29 1999
7273749 Container for carrying out and monitoring biological processes 40 2000
6232079 PCR method for nucleic acid quantification utilizing second or third order rate constants 63 2000
6569627 Monitoring hybridization during PCR using SYBR.TM. Green I 87 2001
7238321 Method for rapid thermal cycling of biological samples 27 2004
7745205 Container for carrying out and monitoring biological processes 7 2004
* 2005/0064,582 Container for carrying out and monitoring biological processes 24 2004
 
GEN-PROBE INCORPORATED (48)
6605213 Method and apparatus for performing a magnetic separation purification procedure on a sample solution 124 2000
6764649 Transport mechanism 74 2001
7033820 Automated system for isolating and amplifying a target nucleic acid sequence 39 2001
6890742 Automated process for isolating and amplifying a target nucleic acid sequence 94 2001
7267795 Incubator for use in an automated diagnostic analyzer 57 2002
7135145 Device for agitating the fluid contents of a container 38 2002
7118892 Automated process for preparing and amplifying a target nucleic acid sequence 40 2002
7384600 Multiple ring assembly for providing specimen to reaction receptacles within an automated analyzer 10 2002
7396509 Instrument for detecting light emitted by the contents of a reaction receptacle 13 2003
7560255 Automated process for detecting the presence of a target nucleic acid in a sample 34 2004
7666681 Method for agitating the fluid contents of a container 17 2005
7560256 Automated process for detecting the presence of a target nucleic acid in a sample 28 2005
7524652 Automated process for detecting the presence of a target nucleic acid in a sample 29 2005
7482143 Automated process for detecting the presence of a target nucleic acid in a sample 29 2005
8615368 Method for determining the amount of an analyte in a sample 6 2006
8008066 System for performing multi-formatted assays 43 2006
7964413 Method for continuous mode processing of multiple reaction receptacles in a real-time amplification assay 24 2006
7932081 Signal measuring system for conducting real-time amplification assays 8 2006
7897337 Method for performing multi-formatted assays 10 2006
7794659 Signal measuring system having a movable signal measuring device 9 2006
7547516 Method for reducing the presence of amplification inhibitors in a reaction receptacle 1 2006
8012419 Temperature-controlled incubator having rotatable door 5 2007
8137620 Temperature-controlled incubator having an arcuate closure panel 3 2007
9598723 Automated analyzer for performing a nucleic acid-based assay 0 2007
8337753 Temperature-controlled incubator having a receptacle mixing mechanism 2 2007
8318500 Method for agitating the contents of a reaction receptacle within a temperature-controlled environment 3 2007
8192992 System and method for incubating the contents of a reaction receptacle 17 2007
7666602 Method for agitating the fluid contents of a container 22 2007
8309358 Method for introducing a fluid into a reaction receptacle contained within a temperature-controlled environment 2 2007
7638337 System for agitating the fluid contents of a container 5 2007
8569019 Method for performing an assay with a nucleic acid present in a specimen 1 2007
8569020 Method for simultaneously performing multiple amplification reactions 2 2008
8546110 Method for detecting the presence of a nucleic acid in a sample 1 2008
8440429 Method for detecting the presence of a nucleic acid in a sample 0 2008
8501461 System for performing multi-formatted assays 12 2009
8663922 Systems and methods for detecting multiple optical signals 1 2010
8349564 Method for continuous mode processing of the contents of multiple reaction receptacles in a real-time amplification assay 13 2010
9372156 System for processing contents of a receptacle to detect an optical signal emitted by the contents 1 2011
8828654 Methods for manipulating liquid substances in multi-chambered receptacles 2 2011
9046507 Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure 0 2011
8221682 System for incubating the contents of a reaction receptacle 2 2011
8718948 Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector 0 2012
8709814 Method for incubating the contents of a receptacle 0 2012
9744506 Instruments for mixing the contents of a detection chamber 0 2013
8784745 Methods for manipulating liquid substances in multi-chambered receptacles 6 2013
8883455 Method for detecting the presence of a nucleic acid in a sample 1 2013
9726607 Systems and methods for detecting multiple optical signals 0 2014
9150908 Method for detecting the presence of a nucleic acid in a sample 1 2014
 
Stragene California (1)
7081600 Method and apparatus for cover assembly for thermal cycling of samples 16 2005
 
BANK OF AMERICA, N.A. (1)
* 2005/0145,273 Thermal cycler for PCR 25 2005
 
APPLIED BIOSYSTEMS, LLC (30)
* 5475610 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control 254 1992
5333675 Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps 186 1993
* 5656493 System for automated performance of the polymerase chain reaction 310 1994
* 5710381 Two piece holder for PCR sample tubes 61 1994
* 6015534 PCR sample tube 50 1995
* 5602756 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control 157 1995
7133726 Thermal cycler for PCR 36 1998
6703236 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control 42 2000
* 7537377 Thermal cycler for PCR 5 2005
* 7504241 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control 12 2006
* 2008/0138,887 Thermal Cycler for Automatic Performance of the Polymerase Chain Reaction with Close Temperature Control 1 2006
7727479 Device for the carrying out of chemical or biological reactions 2 2006
* 2006/0228,268 Device for the carrying out of chemical or biological reactions 23 2006
* 7611674 Device for the carrying out of chemical or biological reactions 4 2007
* 2007/0140,926 Device for the carrying out of chemical or biological reactions 3 2007
* 2007/0110,634 Device for the carrying out of chemical or biological reactions 18 2007
9044753 Thermal cycler for PCR 0 2007
8685717 Thermal cycler for PCR 0 2007
* 2007/0113,880 Thermal cycler for PCR 0 2007
7645070 Thermal cycler for PCR 9 2007
* 2007/0230,535 Thermal cycler for PCR 3 2007
8676383 Device for carrying out chemical or biological reactions 0 2007
* 2008/0274,511 DEVICE FOR CARRYING OUT CHEMICAL OR BIOLOGICAL REACTIONS 28 2007
* 2010/0112,683 Thermal Cycler for Automatic Performance of the Polymerase Chain Reaction with Close Temperature Control 2 2007
* 2008/0299,651 Thermal cycle for automatic performance of the polymerase chain reaction with close temperature control 6 2007
9776187 Thermal cycler for PCR 0 2008
8246243 Thermal cycler for PCR 3 2010
8389288 Device for the carrying out of chemical or biological reactions 0 2010
* 8721972 Device for the carrying out of chemical or biological reactions 1 2012
9457351 Device for carrying out chemical or biological reactions 0 2014
 
APPLIED BIOSYSTEMS INC. (1)
* 2009/0155,765 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control 8 2008
 
GENETEC CORPORATION (2)
* 5281516 Temperature control apparatus and method 96 1992
* RE35716 Temperature control apparatus and method 51 1996
 
SEQUENOM, INC. (1)
* 2003/0113,233 Resin dispensing device 16 2002
 
MALLINCKRODT INC. (2)
8563907 Radiopharmaceutical heater 0 2009
* 2011/0008,222 Radiopharmaceutical Heater 3 2009
 
OLDENBURG, KEVIN R. (1)
7373968 Method and apparatus for manipulating an organic liquid sample 1 2004
 
ROCHE DIAGNOSTICS CORPORATION (3)
* 5616301 Thermal cycler 85 1994
* 5720406 Reaction container arrangement for use in a thermal cycler 34 1996
* 5795547 Thermal cycler 130 1996
 
IDAHO TECHNOLOGY, INC. (1)
7670832 System for fluorescence monitoring 10 2005
 
MERCK SHARP & DOHME CORP. (1)
* 2013/0084,227 HEAT BLOCK WITH INSULATING COLLAR 2 2012
 
SYMYX TECHNOLOGIES, INC. (1)
* 2002/0164,275 Combinatorial chemistry reactor system 13 2002
 
ABBOTT LABORATORIES (1)
* 5415839 Apparatus and method for amplifying and detecting target nucleic acids 235 1993
 
BIO-RAD LABORATORIES, INC. (1)
* 6004512 Sample cartridge slide block 41 1995
 
TRINITY BIOTECH MANUFACTURING LIMITED AND TRINITY BIOTECH, PLC (1)
* 5646046 Method and instrument for automatically performing analysis relating to thrombosis and hemostasis 91 1995
 
APPLERA CORPORATION (4)
7238517 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control 5 2003
* 2004/0086,927 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control 9 2003
* 2006/0286,659 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control 2 2006
* 2006/0269,641 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control 12 2006
 
3-DIMENSIONAL PHARMACEUTICALS, INC. (1)
* 2003/0064,508 Conductive microtiter plate 12 2002
 
BROOKS AUTOMATION, INC. (5)
* 5601141 High throughput thermal cycler 153 1992
6640891 Rapid thermal cycling device 14 2000
7025120 Rapid thermal cycling device 2 2003
* 2003/0217,840 Rapid thermal cycling device 0 2003
7614444 Rapid thermal cycling device 0 2004
 
DAKO DENMARK A/S (10)
6183693 Random access slide stainer with independent slide heating regulation 128 1998
* 6096271 Random access slide stainer with liquid waste segregation 126 1998
6541261 Method using a slide stainer with independent slide heating regulation 81 2000
7718435 Automated slide stainer with slide housing 11 2000
6783733 Random access slide stainer with independent slide heating regulation 66 2001
* 2002/0054,830 Random access slide stainer with independent slide heating regulation 4 2001
* 2004/0191,128 Slide stainer with heating 31 2004
7217392 Random access slide stainer with independent slide heating regulation 24 2004
7553672 Random access slide stainer with independent slide heating regulation 15 2007
* 2007/0281,364 Random access slide stainer with independent slide heating regulation 2 2007
 
QUALIGEN, INC. (8)
8765367 Methods and instruments for processing a sample in a multi-chambered receptacle 0 2008
8735055 Methods of concentrating an analyte 3 2008
8048375 Gravity-assisted mixing methods 17 2008
7780336 Instruments and methods for mixing the contents of a detection chamber 11 2008
7767447 Instruments and methods for exposing a receptacle to multiple thermal zones 27 2008
8052929 Gravity-assisted mixing methods 23 2011
8480976 Instruments and methods for mixing the contents of a detection chamber 20 2011
8491178 Instruments and methods for mixing the contents of a detection chamber 19 2012
 
LIFE TECHNOLOGIES CORPORATION (3)
* 2010/0173,400 Thermal Cycler for PCR 3 2010
* 2010/0120,099 Device For The Carrying Out Of Chemical or Biological Reactions 5 2010
* 2012/0264,206 Device for the Carrying Out of Chemical or Biological Reactions 0 2012
 
SHIMADZU CORPORATION (1)
* 6141975 Sample cooler 5 1999
 
ABBOTT LABORATORIES (1)
* 5576218 Method for thermal cycling nucleic acid assays 26 1995
 
AGILENT TECHNOLOGIES, INC. (8)
* 6657169 Apparatus for thermally cycling samples of biological material with substantial temperature uniformity 37 1999
6730883 Flexible heating cover assembly for thermal cycling of samples of biological material 55 2002
6962821 Thermal cycler including a temperature gradient block 13 2002
* 2003/0157,563 Thermal cycler including a temperature gradient block 8 2002
7005617 Apparatus and method for thermally cycling samples of biological material with substantial temperature uniformity 7 2003
* 2004/0149,725 Apparatus and method for thermally cycling samples of biological material with substantial temperature uniformity 2 2003
6878905 Apparatus and method for flexible heating cover assembly for thermal cycling of samples of biological material 9 2004
* 2005/0184,042 Method and apparatus for cover assembly for thermal cycling of samples 5 2005
 
IGENE, INC. (1)
* 5840573 Molecular analyzer and method of use 25 1996
 
UNISYS CORPORATION (1)
* 5123477 Thermal reactor for biotechnological processes 24 1989
 
KANAGAWA UNIVERSITY (2)
* 9400128 Temperature control device and temperature element 0 2012
* 2014/0130,518 TEMPERATURE CONTROL DEVICE AND TEMPERATURE ELEMENT 0 2012
 
MERCK PATENT GMBH (2)
* 7431891 Device for controlling the temperature of chemical microreactors 1 2001
* 2004/0028,562 Device for controlling the temperature of microcomponents 1 2003
 
UNIVERSITY OF HOUSTON SYSTEM (1)
* 2005/0158,865 System for testing catalysts at elevated pressures 1 2005
 
Eyela-Chino Inc. (1)
7182130 Sample temperature regulator 1 2005
 
D-Eppendorf AG (1)
* 7074367 Thermostated block with heat-regulating devices 10 2004
* Cited By Examiner