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Abstract

The present invention is directed to a method of controlling hyperlipidemia in mammals which comprises administering to a mammal an amount effective to control hyperlipidemia of a compound having hypolipidemic activity and the structural formula: ##STR1## wherein R.sup.1 is hydrogen, a C.sub.1 to C.sub.18 alkyl or substituted alkyl, a C.sub.2 to C.sub.18 alkenyl or substituted alkenyl, a C.sub.2 to C.sub.18 alkynyl or substituted alkynyl, a C.sub.4 to C.sub.10 cycloalkyl or substituted cycloalkyl, a C.sub.4 to C.sub.10 cycloalkenyl or substituted cycloalkenyl, phenyl, a substituted phenyl, cyano, phenalkyl, --CO--R.sup.9 or --Y--CO--R.sup.9 ; R.sup.2 is ##STR2## R.sup.3 and R.sup.4 can be the same or different and are each the same as R.sup.1 ; R.sup.5, R.sup.6 and R.sup.7 can be the same or different and are each hydrogen, a C.sub.1 to C.sub.18 alkyl or substituted alkyl, a C.sub.2 to C.sub.18 alkenyl or substituted alkenyl, a C.sub.1 to C.sub.18 alkynyl or substituted alkynyl, a C.sub.4 to C.sub.10 cycloalkyl or substituted cycloalkyl, a C.sub.4 to C.sub.10 cycloalkenyl or substituted cycloalkenyl, phenyl or substituted phenyl, phenalkyl, --CO--R.sup.9, or --Y--CO--R.sup.9, with the proviso that R.sup.5 and R.sup.6 together cannot be so bulky as to cause the compound to decompose; R.sup.8 is hydrogen, a C.sub.1 to C.sub.5 alkyl, a C.sub.4 to C.sub.10 cycloalkyl, --CO--R.sup.9 or Y--CO--R.sup.9 ; R.sup.9 is hydrogen, a C.sub.1 to C.sub.5 alkyl or substituted alkyl, a C.sub.2 to C.sub.5 alkenyl or substituted alkenyl, a C.sub.2 to C.sub.5 alkynyl or substituted alkynyl, phenyl or substituted phenyl, phenoxy or substituted phenoxy, a C.sub.1 to C.sub.5 alkoxy or substituted alkoxy, a C.sub.4 to C.sub.10 cycloalkyl or substituted cycloalkyl, a C.sub.4 to C.sub.10 cycloalkenyl or substituted cycloalkenyl, --NHC.sub.6 C.sub.5l , --NR.sup.10 R.sup.11 wherein R.sup.10 and R.sup.11 can be the same or different and are each hydrogen, a C.sub.1 to C.sub.5 alkyl or substituted alkyl, phenyl or substituted phenyl; Y is a C.sub.1 to C.sub.10 alkylene or substituted alkylene; R.sup.12 is --CO, --COH, --CS, --CSH, or a C.sub.1 to C.sub.4 alkylene group; and and the pharmaceutically acceptable salts, and mixtures thereof.

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First Claim