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Abstract

Compounds of the formula ##STR1## wherein: z is O or I; X is ##STR2## a and b are 0, 1, or 2 and a+b=0, 1 or 2; R, R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each independently hydrogen, alkyl or aralkyl; R.sub.n is hydrogen, alkyl, aralkyl, acyl, carbalkoxy, carbamyl, carbalkoxyalkyl, hydroxyalkyl, alkoxyalkyl or amidino; R.sup.5 groups on vicinal carbon atoms may together form a carbon-carbon double bond when a or b=2; R groups on vicinal carbon atoms may together form a carbon-carbon double bond when R.sub.n is hydrogen and z=1; R.sup.4 and R.sup.5 geminal groups may together form a spiro substituent, --(CH.sub.2).sub.d --, where d is 2 to 5; R.sup.5 and R.sup.6 groups may together form a carbon-nitrogen double bond when R.sub.3 is hydrogen and a+b=1; R.sup.2 is hydrogen or --(CH.sub.2).sub.y --Y where y is 1-3; Y is hydrogen, --O--R.alpha., --S-R.alpha. or ##STR3## R.alpha. is hydrogen, alkyl, cycloalkyl or acyl; R.beta. is hydrogen or alkyl; and R.alpha. and R.beta. together may form a 3-7 membered ring which may also contain 0-2 additional hetero atoms selected from N, O and S; provided that when a+b=0 and z is 1, then at least one of R.sub.n, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is other than hydrogen; and pharmaceutically acceptable salts thereof, and methods for increasing cardiac contractility using said compounds.

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First Claim