Triterpene saponins having anti-inflammatory, mucolytic and antiedemic activities, process for the preparation thereof and pharmaceutical compositions containing them
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United States of America Patent
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Nov 7, 1989
Grant Date -
N/A
app pub date -
Jun 26, 1987
filing date -
Jul 1, 1986
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Triterpene saponins of formula ##STR1## wherein R.sub.1 is H or OH and R.sub.2 is a tetrasaccharide, or alternatly pentasaccharide, chain have antiinflammatory, mucolytic and antiedemic activities. Said saponins are isolated from roots and bark of Crossopteryx febrifuga, for instance by precipitating them, in form of a complex with cholesterol or sytosterol, from an alcoholic extract of the vegetal material and by partitioning the precipitate between an apolar solvent, which subtracts the complexing agent and a polar solvent in which saponins are soluble.
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