Dry direct compression compositions for controlled release dosage forms
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United States of America Patent
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Nov 21, 1989
Issued Date -
N/A
app pub date -
Nov 24, 1987
filing date -
May 31, 1983
priority date (Note) -
Expired
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Abstract
The selection of: a hydrophobic carbohydrate polymer, e.g. ethyl cellulose; and, generally at least one digestive-difficulty soluble component, i.e. a wax, e.g. carnauba wax, fatty acid material or neutral lipid provides upon dry direct compression a controlled and continuous release matrix for tablets or implants of biologically active agents. Preferred for producing dry direct compressed products is the combination of: a hydrophobic cellulose derivative; a wax, and, a fatty acid material and/or a neutral lipid since it provides upon dry direct compression a controlled and continuous release tablet or implant of improved structurally integrity against externally imposed forces.
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