Novel bis(2,2-dimethyl-1-aziridinyl) phosphinic amides for use in the treatment of tumors
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United States of America Patent
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Dec 12, 1989
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app pub date -
Mar 2, 1988
filing date -
Apr 12, 1982
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Abstract
A method of inhibiting the replication of tumor cells is disclosed wherein Novel bis (2,2-dimethyl-1-aziridinyl)phosphinic amide antineoplastic agents of the formula: ##STR1## wherein X is R and R' are each, independently, hydrogen, alkyl, substituted alkyl, phenyl and substituted phenyl, Y is alkyl or substituted alkyl of 1-10 carbon atoms and, Z is oxygen or sulfur is administered to tumor cells.
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