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Abstract

A process for the cross-flow filtration of a liquid comprising circulating the liquid tangential to a charge modified organic polymeric microporous filter membrane. Preferably, the membrane comprises an organic polymeric microporous filter membrane which has a micro-structure throughout the membrane and an amount of a charge modifying agent bound to substantially all of the membrance micro-structure without substantial pore size reduction or pore blockage. The process may be used for the filtration of liquids, particularly parenteral or biological liquids contaminated with charged particulate and for plasmapheresis, particularly in the form of hollow fiber tubes.

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First Claim