Coating medical devices with cationic antibiotics
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United States of America Patent
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Jan 23, 1990
Issued Date -
N/A
app pub date -
Jun 15, 1988
filing date -
Jul 25, 1986
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A medical device having long-lasting bactericidal properties and a method for making the same is provided. The material from which the medical device is made, the substrate, carries a negatively-charged group having a pKa of less than 6. A cationic antibiotic is ionically bonded to the negatively-charged group. The negatively-charged group may be a portion of a larger carrier molecule. The carrier molecule is bound to the substrate such that the negatively-charged group is exposed for ionic interaction with the cationic antibiotic. Heparin is an ideal carrier molecule because it has both anti-bacterial adhesion activity and anti-thrombogenic activity.
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