Sustained release ibuprofen formulation including a core of ibuprofen and a microcrystalline cellulose and a covering of acrylic polymer and hydroxylated cellulose derivative
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United States of America Patent
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Feb 13, 1990
Grant Date -
N/A
app pub date -
Jul 30, 1987
filing date -
Aug 1, 1986
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides a sustained release .alpha.methyl-4-(2-methylpropyl)benzene acetic acid (Ibuprofen) formulation comprising sufficient granules to provide a predetermined dose or number of doses of Ibuprofen, each granule having a diameter between 0.5 and 2.0 mm and comprising: (a) a core containing 100 parts of Ibuprofen and from 10 to 70 parts of a microcrystalline cellulose; and (b) a coating covering substantially the whole surface of the core and comprising 100 parts of a water insoluble but water swellable acrylic polymer and 20 to 70 parts of a water-soluble hydroxylated cellulose derivative, the weight of the coating being from 5 to 20% of the weight of the core.
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