Antibody combining sites that exhibit amide or ester synthase activity
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United States of America Patent
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Feb 13, 1990
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N/A
app pub date -
May 28, 1987
filing date -
May 28, 1987
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Expired
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Abstract
A phosphorous-containing analog-ligand having a conformation that substantially corresponds to the conformation of an amide- or ester-forming transition state is used to induce production of receptor molecules whose antibody combining sites have amide or ester synthase catalytic activity when reacted with a ligand containing (i) a carbonyl carbon atom and (ii) an amine or alcohol group that are structurally capable of forming a preselected carboxylic amide or ester bond.
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