Asymmetrical ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acid
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United States of America Patent
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Feb 13, 1990
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app pub date -
Sep 22, 1988
filing date -
Apr 2, 1986
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Expired
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Abstract
The present invention relates to novel asymmetrical esters derived from 1,4-dihydropyridine-3,5-dicarboxylic acid, of the formula: ##STR1## in which: R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group, R.sub.2 represents a C.sub.1 -C.sub.4 alkyl group, a benzyl group, a benzoyl group or a phenyl group optionally substituted by one or more C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, cyano, nitro, hydroxyl or trifluoromethyl groups or by one or more halogen atoms, and R.sub.3 and R.sub.4, which are identical or different, each represent the hydrogen atom, a nitro group or a chlorine atom, their optical isomers and diastereoisomers and also the corresponding addition salts. These novel esters are useful in therapy, especially as antihypertensives.
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