Novel amphiphilic nucleic acid conjugates
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United States of America Patent
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Feb 27, 1990
Grant Date -
N/A
app pub date -
Jun 11, 1987
filing date -
Jun 11, 1987
priority date (Note) -
Expired
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Abstract
Novel oligonucleotide conjugates are provided, where oligonucleotides are joined through a linking arm to a hydrophobic moiety. The resulting conjugates are more efficient in membrane transport, so as to be capable of crossing the membrane and effectively modulating a transcriptional system. In this way, the compositions can be used in vitro and in vivo, for studying cellular processes, protecting mammalian hosts from pathogens, and the like.
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