Intermediates for preparing 1,6-dicarba-vasopressin compounds
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United States of America Patent
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Mar 13, 1990
Issued Date -
N/A
app pub date -
May 9, 1988
filing date -
Jan 16, 1986
priority date (Note) -
Expired
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Abstract
New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
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