CDNA clone encoding brain amyloid of alzheimer's disease
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United States of America Patent
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Mar 27, 1990
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N/A
app pub date -
Feb 26, 1987
filing date -
Feb 26, 1987
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Expired
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Abstract
Four clones have been isolated from an adult human brain cDNA library using an oligonucleotide probe corresponding to the first 20 amino acids of the brain amyloid polypeptide of the Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids including the known amino acid sequence of this polypeptide. The 3.5 kb messenger RNA has been detected in mammalian brains and human thymus. The gene is highly conserved in evolution and been mapped to human chromosome 21.
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