Diuretic and saluretic 4-chloro-3-sulfamoylbenzoic acid hydrazides
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United States of America Patent
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Apr 10, 1990
Grant Date -
N/A
app pub date -
Dec 29, 1988
filing date -
Dec 30, 1987
priority date (Note) -
Expired
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Abstract
The present invention relates to novel compounds of the general formula ##STR1## wherein R is hydrogen atom or a trifluoromethyl, carboxy, C.sub.2-5 alkoxycarbonyl, cyano, benzoyl, sulfamoyl or C.sub.1-4 alkylsulfonyl group; R.sup.1 is hydrogen atom or a linear or branched chain C.sub.1-4 alkyl, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulfonyl, benzylthio, benzylsulfonyl, phenyl, hydroxy or mercapto group; and R.sup.2 is hydrogen or chlorine atom, as well as their pharmaceutically acceptable salts. The compounds according to the invention possess diuretic and saluretic activity with an advantageous Na/K ratio.
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