Aromatic derivatives, their preparation and their use as antimicrobial agents

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United States of America Patent

PATENT NO 4916156
SERIAL NO

07178327

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to aromatic derivatives of the formula: ##STR1## in which: n represents an integer between 2 and 10; R.sub.1 and R.sub.2 are identical or different and represent a cycloalkyl containing 3 to 6 carbon atoms or an alkyl containing from 1 to 6 carbon atoms which is unsubstituted or substituted by a phenyl or benzyl group; or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are bonded, form a heterocycle selected from pyrrolidin-1-yl, piperidino, azepin-1-yl, hexamethyleneimino, 4-methylpiperidino, 4-benzylpiperidino, 4-phenylpiperidino, 1,2,3,4-tetrahydroisoquinol-2-yl, morpholino and imidazol-1-yl groups; R.sub.3 represents a hydrogen, a halogen, a methyl or a phenyl; R.sub.4 represents a hydrogen, a halogen or a methyl; or R.sub.3 and R.sub.4, taken together with the benzene ring to which they are bonded, form a naphth-1-yl or naphth-2-yl group; Y represents a direct bond, a methyleneoxy group, a methylenethio group or a vinylene group; and R.sub.5 represents an alkyl containing from 5 to 18 carbon atoms, a cycloalkyl containing from 3 to 8 carbon atoms, an adamantyl, naphth-1-yl or naphth-2-yl group, an unsubstituted phenyl group or a phenyl group substituted by one or 2 substituents selected from halogen atoms, the trifluoromethyl group, the nitro group and the phenyl group; and to their salts with mineral or organic acids.

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Patent Owner(s)

Patent OwnerAddress
ELF SANOFI32/34 RUE MARBEUF 75008 PARIS

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mosse, Madeleine Montpellier, FR 7 42
Proietto, Vincenzo Saint-Georges D'Orques, FR 50 551

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