Fluorine-containing protoporphyrin derivatives and their salts
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United States of America Patent
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Apr 10, 1990
Grant Date -
N/A
app pub date -
Nov 4, 1988
filing date -
Nov 9, 1987
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Disclosed herein is a fluorine-containing protoporphyrin derivative of formula (I): ##STR1## wherein R.sub.1 and R.sub.2 each independently is --CH.dbd.CH.sub.2 or --CH.dbd.CF.sub.2 with the proviso that R.sub.1 and R.sub.2 cannot both be --CH.dbd.CH.sub.2 ; and salts thereof. They have remarkable property of peculiarly concentrating or accumulating in the cancer tissues, and very useful as a diagnostic agent of minute cancer in a NMR diagnosis method.
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