Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
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United States of America Patent
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Apr 17, 1990
Issued Date -
N/A
app pub date -
Dec 11, 1987
filing date -
Jun 26, 1985
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is .beta.-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is not water-soluble or not readily soluble in water at pH 6-8 without such solubilizing agent, is selectively conjugated to a water-soluble polymer selected from polyethylene glycol homopolymers or polyoxyethylated polyols.
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