Method for detecting the ability to prevent red-to-green congophilic birefringence
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United States of America Patent
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Apr 24, 1990
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N/A
app pub date -
Feb 27, 1989
filing date -
Mar 3, 1987
priority date (Note) -
Expired
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Abstract
A method for detecting the ability of a compound to prevent development of red-to-green congophilic birefringence. The method is carried out by contacting the compound with dense microspheres which are derived from mammalian brain tissue and which, when disrupted, display red-to-green congophilic birefringence upon staining with Congo Red dye under conditions such that said dense microspheres are disrupted. Thereafter the disrupted dense microspheres are stained with Congo Red dye and any development of red-to-green congophilic birefringence in the stained disrupted dense microspheres is detected.
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